Losartan potassium | Angiotensin AT1 antagonist
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 100 mg | $40.00 | ||
| 500 mg | $160.00 |
Losartan potassium (124750-99-8) is a non-peptide angiotensin II receptor antagonist.1,2 Clinically useful antihypertensive agent.3 Inhibits collagen I synthesis.4 Induces SIRT1 expression and activity and reduces hepatic injury in a rat reduced-size orthotopic liver transplantation model.5 Losartan potassium displays neuroprotective effects along with nimesulide (Cat.# 10-1161) against chronic fatigue stress.6 Displays myocardial antifibrotic activity.7
References/Citations:
1) Merck 14:5583
2) Chiu et al. (1990), Nonpeptide angiotensin II receptor antagonists. VII. Cellular and biochemical pharmacology of DuP 753, an orally active antihypertensive agent; J. Pharmacol. Exp. Ther., 252 711
3) McIntyre et al. (1997), Losartan, an orally active angiotensin (AT1) receptor antagonist: a review of it’s efficacy and safety in essential hypertension; Pharmacol. Ther., 74 181
4) Diop-Frimpong et al. (2011), Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors; Proc. Natl. Acad. Sci. USA, 108 2909
5) Pantazi et al. (2015), Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation; World J. Gastroenterol., 21 8021
6) Kumar et al. (2015), Neuroprotective mechanism of losartan and its interaction with nimesulide against chronic fatigue stress; Inflammopharmacology, 23 291
7) Miguel-Carrasco et al. (2017), Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites; Sci. Rep. 7 41865
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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Losartan potassium (124750-99-8) is a non-peptide angiotensin II receptor antagonist.1,2 Clinically useful antihypertensive agent.3 Inhibits collagen I synthesis.4 Induces SIRT1 expression and activity and reduces hepatic injury in a rat reduced-size orthotopic liver transplantation model.5 Losartan potassium displays neuroprotective effects along with nimesulide (Cat.# 10-1161) against chronic fatigue stress.6 Displays myocardial antifibrotic activity.7
References/Citations:
1) Merck 14:5583
2) Chiu et al. (1990), Nonpeptide angiotensin II receptor antagonists. VII. Cellular and biochemical pharmacology of DuP 753, an orally active antihypertensive agent; J. Pharmacol. Exp. Ther., 252 711
3) McIntyre et al. (1997), Losartan, an orally active angiotensin (AT1) receptor antagonist: a review of it’s efficacy and safety in essential hypertension; Pharmacol. Ther., 74 181
4) Diop-Frimpong et al. (2011), Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors; Proc. Natl. Acad. Sci. USA, 108 2909
5) Pantazi et al. (2015), Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation; World J. Gastroenterol., 21 8021
6) Kumar et al. (2015), Neuroprotective mechanism of losartan and its interaction with nimesulide against chronic fatigue stress; Inflammopharmacology, 23 291
7) Miguel-Carrasco et al. (2017), Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites; Sci. Rep. 7 41865
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