Lovastatin | HMG-CoA reductase inhibitor
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 100 mg | $50.00 | ||
| 500 mg | $165.00 |
Lovastatin (75330-75-5) Blocks cholesterol and isoprenoid biosynthesis via inhibition of HMG-CoA reductase (Ki=1nM for acid form).1,2 Induces apoptosis in various cell lines.3 Causes cell cycle arrest in early G1 phase.4 Lovastatin is a clinically useful antihyperlipemic agent.5 Cell permeable.
References/Citations:
1) Alberts et al. (1988), Discovery, biochemistry and biology of lovastatin; Am. J. Cardiol., 62 10J
2) Hancock et al. (1989), All ras proteins are polyisoprenylated but only some are palmitoylated; Cell, 57 1167
3) Park et al. (1999), Lovastatin-induced inhibition of HL-60 cell proliferation via cell cycle arrest and apoptosis; Anticancer Res., 19 3133
4) Vilimanovich et al. (2015), Statin-mediated inhibition of cholesterol synthesis induces cytoprotective autophagy in human leukemic cells; Eur. J. Pharmacol., 765 415
5) Tobert et al. (1988), Efficacy and long-term adverse effect pattern of lovastatin; Am. J. Cardiol., 62 28J
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Lovastatin (75330-75-5) Blocks cholesterol and isoprenoid biosynthesis via inhibition of HMG-CoA reductase (Ki=1nM for acid form).1,2 Induces apoptosis in various cell lines.3 Causes cell cycle arrest in early G1 phase.4 Lovastatin is a clinically useful antihyperlipemic agent.5 Cell permeable.
References/Citations:
1) Alberts et al. (1988), Discovery, biochemistry and biology of lovastatin; Am. J. Cardiol., 62 10J
2) Hancock et al. (1989), All ras proteins are polyisoprenylated but only some are palmitoylated; Cell, 57 1167
3) Park et al. (1999), Lovastatin-induced inhibition of HL-60 cell proliferation via cell cycle arrest and apoptosis; Anticancer Res., 19 3133
4) Vilimanovich et al. (2015), Statin-mediated inhibition of cholesterol synthesis induces cytoprotective autophagy in human leukemic cells; Eur. J. Pharmacol., 765 415
5) Tobert et al. (1988), Efficacy and long-term adverse effect pattern of lovastatin; Am. J. Cardiol., 62 28J
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