Loxoribine | TLR7 agonist
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $30.00 | ||
| 25 mg | $70.00 |
Loxoribine (21288-39-9) is a toll-like receptor 7 (TLR7) agonist.1 A potent immunostimulant with a relatively broad spectrum of immunobiological activities including upregulation of the activity of B cells, T cells, NK cells, macrophages and LAK cells.2 Induces secretion of IFN-γ by NK cells.3 Inhibits influenza A infection in chickens.4 Induces tumor regression by reversing Treg-induced immunosuppression.5
References/Citations:
1) Heil et al. (2003), The Tool-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily; Eur. J. Immunol., 33 2987
2) Goodman et al. (1995), A new approach to vaccine adjuvants. Immunopotentiation by intracellular T-helper-like signals transmitted by loxoribine; Pharm. Biotechnol., 6 581
3) Girart et al. (2007), Engagement of TLR3, TLR7 and NKG2D regulate IFN-gamma secretion but not NKG2D-mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12; J. Immunol., 179 3472
4) Stewart et al. (2012), Toll-like receptor 7 ligands inhibit influenza A infection in chickens; J. Interferon Cytokine Res,, 32 46
5) Wang et al. (2015), The TLR7 agonist induces tumor regression both by promoting CD4-T cells proliferation and by reversing T regulatory cell-mediated suppression via dendritic cells; Oncotarget, 6 1779
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Loxoribine (21288-39-9) is a toll-like receptor 7 (TLR7) agonist.1 A potent immunostimulant with a relatively broad spectrum of immunobiological activities including upregulation of the activity of B cells, T cells, NK cells, macrophages and LAK cells.2 Induces secretion of IFN-γ by NK cells.3 Inhibits influenza A infection in chickens.4 Induces tumor regression by reversing Treg-induced immunosuppression.5
References/Citations:
1) Heil et al. (2003), The Tool-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily; Eur. J. Immunol., 33 2987
2) Goodman et al. (1995), A new approach to vaccine adjuvants. Immunopotentiation by intracellular T-helper-like signals transmitted by loxoribine; Pharm. Biotechnol., 6 581
3) Girart et al. (2007), Engagement of TLR3, TLR7 and NKG2D regulate IFN-gamma secretion but not NKG2D-mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12; J. Immunol., 179 3472
4) Stewart et al. (2012), Toll-like receptor 7 ligands inhibit influenza A infection in chickens; J. Interferon Cytokine Res,, 32 46
5) Wang et al. (2015), The TLR7 agonist induces tumor regression both by promoting CD4-T cells proliferation and by reversing T regulatory cell-mediated suppression via dendritic cells; Oncotarget, 6 1779
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