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Product Details

LY-2183240 | Anandamide uptake inhibitor

LY-2183240 (874902-19-9) is highly potent inhibitor of cellular anandamide uptake (IC50 = 0.27nM1, 15nM2). LY-2183240 has also been found2,3,4 to be an inhibitor of fatty acid amide hydrolase (FAAH) - IC50 = 14nM4, diacylglycerol lipase (DAGL) and monoacylglycerol lipase (MAGL) - IC50 = 5.3 nM3.

References/Citations
1) Moore et al., (2005), Identification of a high-affinity binding site involved in the transport of endocannabinoids; Proc. Natl. Acad. Sci. USA, 102 17852
2) Ortar et al. (2008), Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: A critical revision; Eur. .J. Med. Chem., 43 62
3) Alexander and Cravatt (2006), The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases; J. Am. Chem. Soc., 128 9699
4) Dickason-Chesterfield et al. (2006), Pharmacological Characterization of Endocannabinoid Transport and Fatty Acid Amide Hydrolase Inhibitors; Cell. Mol. Neurobiol., 26 405

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Catalog#  10-2636

$60.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
874902-19-9
Catalog Number:
10-2636
Activity:
Andamide uptake inhibitor
Chemical Name:
5-([1,1'-Biphenyl]-4-ylmethyl)-N,N,-dimethyl-1H-tetrazole-1-carboxamide
Molecular Weight:
307.35
Molecular Formula:
C17H17N5O
Solubility:
Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 15 mg/ml).
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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