LY364947 | ALK5 inhibitor

CAS:
396129-53-6
Catalog Number:
10-1492
Activity:
ALK5 inhibitor
Alternate Names:
HTS-466284
Chemical Name:
4-(3-Pyridin-2-yl-1H-pyrazol-4-yl)quinolone
Molecular Weight:
272.31
Molecular Formula:
C17H12N4
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Brown solid
Purity:
98% by TLC
Storage Temperature:
RT (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

size :PriceQuantity 
5 mg$75.00
25 mg$300.00

LY364947 (396129-53-6) is a selective ALK5 inhibitor, IC50 = 59, 400 and 1400 nM for TGF-β RI, TGF-β RII and MLK-7K, respectively.1 Inhibits Smad2 phosphorylation induced by TGF-β as well as fibronectin expression and MDA-MB-231 cell invasion.2 LY-364947 abolishes resistance of glioblastoma-initiating cells to radiation.3 Cell permeable.

References/Citations:

1) Sawyer et al. (2003), Synthesis and activity of new aryl-and hetero-aryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain; J. Med. Chem., 46 3953
2) Shiou et al. (2006), Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-beta; J. Biol. Chem., 281 33971
3) Hardee et al. (2012), Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β; Cancer Res., 72 4119

CAS:
396129-53-6
Catalog Number:
10-1492
Activity:
ALK5 inhibitor
Alternate Names:
HTS-466284
Chemical Name:
4-(3-Pyridin-2-yl-1H-pyrazol-4-yl)quinolone
Molecular Weight:
272.31
Molecular Formula:
C17H12N4
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Brown solid
Purity:
98% by TLC
Storage Temperature:
RT (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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