my account
Login
  Loading... Please wait...

Product Details

LY-364947 | ALK5 inhibitor

LY-364947 (396129-53-6) is a selective ALK5 inhibitor, IC50 = 59, 400 and 1400 nM for TGF-β RI, TGF-β RII and MLK-7K, respectively1. Inhibits Smad2 phosphorylation induced by TGF-β as well as fibronectin expression and MDA-MB-231 cell invasion2. LY-364947 abolishes resistance of glioblastoma-initiating cells to radiation3. Cell permeable.

References/Citations
1) Sawyer et al. (2003), Synthesis and activity of new aryl-and hetero-aryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain; J. Med. Chem., 46 3953
2) Shiou et al. (2006), Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-beta; J. Biol. Chem., 281 33971
3) Hardee et al. (2012), Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β; Cancer Res., 72 4119

swipe
Focus Biomolecules cell signaling reagent supplier, chemical structure of LY-364947 | ALK5 inhibitor | CAS 396129-53-6

Catalog#  10-1492

$74.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
396129-53-6
Catalog Number:
10-1492
Activity:
ALK5 inhibitor
Alternate Names:
HTS-466284
Chemical Name:
4-(3-Pyridin-2-yl-1H-pyrazol-4-yl)quinolone
Molecular Weight:
272.31
Molecular Formula:
C17H12N4
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Brown solid
Purity:
98% by TLC
Storage Temperature:
RT (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the LY-364947 | ALK5 inhibitor to your wish list.