LY2090314 | Wnt/ß-Catenin pathway activator/GSK-3 inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $85.00 | ||
| 25 mg | $310.00 |
Wnt/ß-catenin pathway activator. LY2090314 (603288-22-8) is a highly potent (IC50 = 1.5 nM GSK-3α; 0.9 nM GSK-3ß) and selective inhibitor of glycogen synthase-3-kinase (GSK-3).1,2 It stabilized ß-catenin levels and elevated expression of Axin2 leading to tumor growth delays in A375 melanoma xenografts.2 LY2090314 significantly reduced growth in multiple neuroblastoma cell lines.3 It inhibited growth and induced apoptosis in osimertinib-resistant lung cancer cells, specifically those with a mesenchymal phenotype.4
References/Citations:
- Engler et al. (2004), Substituted 3-imidazo[1,2-a]pyridine-3-yl-4-(1,2,3,4-tetrahydro-[1,4]diazepino-[6,7,1=hi]indol-7-yl)pyrrole-2,5-diones as and potent inhibitors of glycogen synthase-3-kinase; J. Med. Chem. 47 3934
- Atkinson et al. (2015), Activating the Wnt/ß-Catenin Pathway for the Treatment of Melanoma – Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3; PLoS One 10 e0125028
- Kunnimalaiyaan et al. (2018), Antiproliferative and apoptotic effect of LY2090314, a GSK-3 inhibitor, in neuroblastoma in vitro BMC Cancer 18 560
- Fukuda et al. (2020), Glycogen synthase kinase-3 inhibition overcomes epithelial-mesenchymal transition-associated resistance to Osimertinib in EGFR-mutant lung cancer; Cancer Sci. 111 2374
C28H25FN6O3
>98% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Wnt/ß-catenin pathway activator. LY2090314 (603288-22-8) is a highly potent (IC50 = 1.5 nM GSK-3α; 0.9 nM GSK-3ß) and selective inhibitor of glycogen synthase-3-kinase (GSK-3).1,2 It stabilized ß-catenin levels and elevated expression of Axin2 leading to tumor growth delays in A375 melanoma xenografts.2 LY2090314 significantly reduced growth in multiple neuroblastoma cell lines.3 It inhibited growth and induced apoptosis in osimertinib-resistant lung cancer cells, specifically those with a mesenchymal phenotype.4
References/Citations:
- Engler et al. (2004), Substituted 3-imidazo[1,2-a]pyridine-3-yl-4-(1,2,3,4-tetrahydro-[1,4]diazepino-[6,7,1=hi]indol-7-yl)pyrrole-2,5-diones as and potent inhibitors of glycogen synthase-3-kinase; J. Med. Chem. 47 3934
- Atkinson et al. (2015), Activating the Wnt/ß-Catenin Pathway for the Treatment of Melanoma – Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3; PLoS One 10 e0125028
- Kunnimalaiyaan et al. (2018), Antiproliferative and apoptotic effect of LY2090314, a GSK-3 inhibitor, in neuroblastoma in vitro BMC Cancer 18 560
- Fukuda et al. (2020), Glycogen synthase kinase-3 inhibition overcomes epithelial-mesenchymal transition-associated resistance to Osimertinib in EGFR-mutant lung cancer; Cancer Sci. 111 2374
Related products
-
Imiquimod | TLR7 Agonist
From $30.00CAS:99011-02-6Catalog Number:10-4230Alternate Name:R837Activity:TLR7 agonistChemical Name:1-(2-Methylpropyl)imidazo[4,5-c]quinolin-4-amineMolecular Weight:240.30Molecular Formula:C14H16N4Solubility:Soluble in DMSO (2 mg/ml with warming)Physical Properties:White solidPurity:>98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Norfluoxetine HCl | Fluoxetine Metabolite
From $60.00CAS:57226-68-3Catalog Number:10-2671Alternate Name:DesmethylfluoxetineActivity:Fluoxetine metaboliteChemical Name:3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine hydrochloride (racemic)Molecular Weight:331.76Molecular Formula:C16H16F3NO HClSolubility:Soluble in DMSO ( up to at least 25 mg/ml)Physical Properties:Beige waxy solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
NOTUMib-1 | NOTUM inhibitor, restores Wnt signaling
From $55.00Catalog Number:10-3756Activity:NOTUM inhibitor, restores Wnt signalingChemical Name:N-(Isoquinolin-6-yl)-2-(o-tolyloxy)acetamideMolecular Weight:292.33Molecular Formula:C18H16N2O2Solubility:Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 5 mg/ml with warming).Physical Properties:Beige solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20° (des.)Stability:Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
