MAC-545496 | GraR inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $195.00 |
MAC-545496 (838810-96-1) is an inhibitor of glycopeptide-resistance-associated protein R (GraR, also known as ApsR). GraR and its regulatory system are important for virulence of S. aureus. MAC-545496 is able to reverse ß-lactam resistance in S. aureus in a G. Mellonella larvae model. 0.06 µg/mL MAC-545496 lowered the minimum inhibitory concentration (MIC) for oxacillin against S. aureus below the CLSI clinical breakpoint. It lowered the ß-lactam MIC from 512 to 8 µg/mL against S. aureus USA300.
References:
- El-Halfawy et al. (2020), Discovery of an antivirulence compound that reverses ß-lactam resistance in MRSA; Nat. Chem. Biol., 16 143
NMR (Conforms)
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Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
MAC-545496 (838810-96-1) is an inhibitor of glycopeptide-resistance-associated protein R (GraR, also known as ApsR). GraR and its regulatory system are important for virulence of S. aureus. MAC-545496 is able to reverse ß-lactam resistance in S. aureus in a G. Mellonella larvae model. 0.06 µg/mL MAC-545496 lowered the minimum inhibitory concentration (MIC) for oxacillin against S. aureus below the CLSI clinical breakpoint. It lowered the ß-lactam MIC from 512 to 8 µg/mL against S. aureus USA300.
References:
- El-Halfawy et al. (2020), Discovery of an antivirulence compound that reverses ß-lactam resistance in MRSA; Nat. Chem. Biol., 16 143
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