Matrine | Induces RIP3-dependent necroptosis
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $30.00 | ||
| 50 mg | $80.00 |
Matrine (519-02-8) is a natural product found in the plant Sophora flavescens. It has been found to possess myriad biological activities including a positive inotropic effect1,2, reduced glucose intolerance and hepatic steatosis in a mouse model via activation of HSP723, various anti-cancer effects4-6. Matrine has also recently been shown to induce RIP3-dependent necroptosis in cholangiocarcinoma cells.7
References/Citations:
1) Zhou et al. (2008), Inotropic effects and mechanisms of matrine, a main alkaloid from Sophora flavescens AIT; Biol. Pharm. Bull. 31 2057
2) Zhou et al. (2014), The alkaloid matrine of the root of Sophora flavescens prevents arrhythmogenic effect of ouabain; Phytomedicine 21 931
3) Zheng et al. (2015), Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target; Br. J. Pharmacol. 172 4303
4) Li et al. (2010), Therapeutic effects of matrine on primary and metastatic breast cancer; Am. J. Chin. Med. 38 1115
5) Li et al. (2015), Matrine inhibited proliferation and increased apoptosis in human breast cancer MCF-7 cells via upregulation of Bax and downregulation of Bcl-2; Int. J. Clin. Exp. Pathol. 8 14793
6) Zhou et al. (2014), Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor; Mol. Cancer 13 Issue 59
7) Xu et al. (2017), Matrine induces RIP3-dependent necroptosis in cholangiocarcinoma cells; Cell Death Discov. 23 16096
NMR (Conforms)
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Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Matrine (519-02-8) is a natural product found in the plant Sophora flavescens. It has been found to possess myriad biological activities including a positive inotropic effect1,2, reduced glucose intolerance and hepatic steatosis in a mouse model via activation of HSP723, various anti-cancer effects4-6. Matrine has also recently been shown to induce RIP3-dependent necroptosis in cholangiocarcinoma cells.7
References/Citations:
1) Zhou et al. (2008), Inotropic effects and mechanisms of matrine, a main alkaloid from Sophora flavescens AIT; Biol. Pharm. Bull. 31 2057
2) Zhou et al. (2014), The alkaloid matrine of the root of Sophora flavescens prevents arrhythmogenic effect of ouabain; Phytomedicine 21 931
3) Zheng et al. (2015), Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target; Br. J. Pharmacol. 172 4303
4) Li et al. (2010), Therapeutic effects of matrine on primary and metastatic breast cancer; Am. J. Chin. Med. 38 1115
5) Li et al. (2015), Matrine inhibited proliferation and increased apoptosis in human breast cancer MCF-7 cells via upregulation of Bax and downregulation of Bcl-2; Int. J. Clin. Exp. Pathol. 8 14793
6) Zhou et al. (2014), Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor; Mol. Cancer 13 Issue 59
7) Xu et al. (2017), Matrine induces RIP3-dependent necroptosis in cholangiocarcinoma cells; Cell Death Discov. 23 16096
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