MCI-186 | Antioxidant

CAS:
89-25-8
Catalog Number:
10-2295
Activity:
Antioxidant-nonphenolic
Alternate Names:
Edaravone
Chemical Name:
3-Methyl-1-phenyl-2-pyrazolin-5-one
Molecular Weight:
174.2
Molecular Formula:
C10H10N2O
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Tan solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
50 mg$35.00
250 mg$90.00

MCI-186 (89-25-8), also known as edaravone,  is an antioxidant free radical scavenger used as a neuroprotective agent following acute brain ischemia and subsequent cerebral infarction.1,2 MCI-186 also protects against MPTP-induced neurotoxicity in the Substantia Nigra.3

References/Citations:

1) Watanabe et al. (1994), Protective effects of MCI-186 on cerebral ischemia:possible involvement of free radical scavenging and antioxidant actions; J. Pharmacol. Exp. Ther., 268 1597
2) Yoshida et al. (2006) Neuroprotective effects of edaravone:a novel free radical scavenger in cerebrovascular injury; CNS Drug Reviews, 12 9
3) Kawasaki et al. (2007) Edaravone (3-Methyl-1-phenyl-2-pyrazolin-5-one), a Radical Scavenger, Prevents 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Neurotoxicity in the Substantia Nigra but Not the Striatum; J. Pharmacol. Exp. Ther., 322 274

CAS:
89-25-8
Catalog Number:
10-2295
Activity:
Antioxidant-nonphenolic
Alternate Names:
Edaravone
Chemical Name:
3-Methyl-1-phenyl-2-pyrazolin-5-one
Molecular Weight:
174.2
Molecular Formula:
C10H10N2O
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Tan solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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