Meleagrin | Met inhibitor, anticancer activity
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 1 mg | $145.00 | ||
| 5 mg | $550.00 |
Meleagrin (71751-77-4) is a novel alkaloid biosynthesized via the roquefortine branched biosynthetic pathway.1,2 Displays excellent ATP-competitive c-MET inhibition, inhibiting the growth, migration and invasion of numerous breast cancer cell lines.3 Also has been shown to inhibit the bacterial enoyl-acyl carrier protein reductase (Fabl) with IC50s in the 33-40 mM range.4
References/Citations:
1) Ries et al. (2013), Novel key metabolites reveal further branching of the roquefortine/meleagrin biosynthetic pathway; J. Biol. Chem., 288 37289
2) Newmister et al. (2016), OxaD: A Versatile Indolic Nitrone Synthase from the Marine-Derived Fungus Penicillium oxalicum F30l; J. Am. Chem. Soc., 138 11176
3) Mady et al. (2016), The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migrations and invasion; Bioorg. Med. Chem., 24 113
4) Zheng et al. (2013), Meleagrin, a new Fabl inhibitor from Penicillium chryosogenum with at least one additional mode of action; PLoS One, 8(11) e78922
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Meleagrin (71751-77-4) is a novel alkaloid biosynthesized via the roquefortine branched biosynthetic pathway.1,2 Displays excellent ATP-competitive c-MET inhibition, inhibiting the growth, migration and invasion of numerous breast cancer cell lines.3 Also has been shown to inhibit the bacterial enoyl-acyl carrier protein reductase (Fabl) with IC50s in the 33-40 mM range.4
References/Citations:
1) Ries et al. (2013), Novel key metabolites reveal further branching of the roquefortine/meleagrin biosynthetic pathway; J. Biol. Chem., 288 37289
2) Newmister et al. (2016), OxaD: A Versatile Indolic Nitrone Synthase from the Marine-Derived Fungus Penicillium oxalicum F30l; J. Am. Chem. Soc., 138 11176
3) Mady et al. (2016), The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migrations and invasion; Bioorg. Med. Chem., 24 113
4) Zheng et al. (2013), Meleagrin, a new Fabl inhibitor from Penicillium chryosogenum with at least one additional mode of action; PLoS One, 8(11) e78922
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