Size : | Price | Quantity | |
---|---|---|---|
1 mg | $145.00 | ||
5 mg | $550.00 |
Meleagrin (71751-77-4) is a novel alkaloid biosynthesized via the roquefortine branched biosynthetic pathway.1,2 Displays excellent ATP-competitive c-MET inhibition, inhibiting the growth, migration and invasion of numerous breast cancer cell lines.3 Also has been shown to inhibit the bacterial enoyl-acyl carrier protein reductase (Fabl) with IC50s in the 33-40 mM range.4
References/Citations:
1) Ries et al. (2013), Novel key metabolites reveal further branching of the roquefortine/meleagrin biosynthetic pathway; J. Biol. Chem., 288 37289
2) Newmister et al. (2016), OxaD: A Versatile Indolic Nitrone Synthase from the Marine-Derived Fungus Penicillium oxalicum F30l; J. Am. Chem. Soc., 138 11176
3) Mady et al. (2016), The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migrations and invasion; Bioorg. Med. Chem., 24 113
4) Zheng et al. (2013), Meleagrin, a new Fabl inhibitor from Penicillium chryosogenum with at least one additional mode of action; PLoS One, 8(11) e78922
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Meleagrin (71751-77-4) is a novel alkaloid biosynthesized via the roquefortine branched biosynthetic pathway.1,2 Displays excellent ATP-competitive c-MET inhibition, inhibiting the growth, migration and invasion of numerous breast cancer cell lines.3 Also has been shown to inhibit the bacterial enoyl-acyl carrier protein reductase (Fabl) with IC50s in the 33-40 mM range.4
References/Citations:
1) Ries et al. (2013), Novel key metabolites reveal further branching of the roquefortine/meleagrin biosynthetic pathway; J. Biol. Chem., 288 37289
2) Newmister et al. (2016), OxaD: A Versatile Indolic Nitrone Synthase from the Marine-Derived Fungus Penicillium oxalicum F30l; J. Am. Chem. Soc., 138 11176
3) Mady et al. (2016), The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migrations and invasion; Bioorg. Med. Chem., 24 113
4) Zheng et al. (2013), Meleagrin, a new Fabl inhibitor from Penicillium chryosogenum with at least one additional mode of action; PLoS One, 8(11) e78922
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