Metergoline | Serotonin 5HT1,2,7 antagonist
CAS:
17692-51-2
Catalog Number:
10-3058
Activity:
Serotonin 5HT1,2,7 antagonist
Chemical Names:
[(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamic acid phenylmethyl ester
Molecular Weight:
403.52
Molecular Formula:
C25H29N3O2
Solubility:
Soluble in DMSO (40 mg/ml) or ethanol (4 mg/mL)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethaqnol may be stored at -20°C for up to 2 month.
Shipping Code:
RT
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $35.00 | ||
| 50 mg | $100.00 |
Metergoline (17692-51-2) is an ergot alkaloid derivative acting as antagonist at serotonin 5HT1 and 5HT2 receptors1,2 and 5HT7 receptors3. A safe and effective agent for management of hyperprolactinemic amenorrhea and anovulation.4 Displays a long-lasting antidepressant effect in seasonal affective disorder.5
References:
- Aulakh et al. (1992), Effects of various serotonin receptor subtype-selective antagonists alone and on m-chlorophenylpiperazine-induced neuroendocrine changes in rats; J. Pharmacol. Exp. Ther., 263 588
- Bagdy et al. (1992), Pharmacological characterization of serotonin receptor subtypes involved in vasopressin and plasma renin activity responses to serotonin agonists; Eur. J. Pharmacol., 210 285
- Knight et al. (2009), Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists; Mol. Pharmacol., 75 374
- Falsetti et al. (1982), Metergoline in the management of hyperprolactinemia amenorrhea and anovulation; Gynecol. Obstet. Invest., 13 108
- Turner et al. (2002), Double-blind, placebo-controlled study of single-dose metergoline in depressed patients with seasonal affective disorder; J. Clin. Psychopharmacol., 22 216
CAS:
17692-51-2
Catalog Number:
10-3058
Activity:
Serotonin 5HT1,2,7 antagonist
Chemical Names:
[(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamic acid phenylmethyl ester
Molecular Weight:
403.52
Molecular Formula:
C25H29N3O2
Solubility:
Soluble in DMSO (40 mg/ml) or ethanol (4 mg/mL)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethaqnol may be stored at -20°C for up to 2 month.
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Metergoline (17692-51-2) is an ergot alkaloid derivative acting as antagonist at serotonin 5HT1 and 5HT2 receptors1,2 and 5HT7 receptors3. A safe and effective agent for management of hyperprolactinemic amenorrhea and anovulation.4 Displays a long-lasting antidepressant effect in seasonal affective disorder.5
References:
- Aulakh et al. (1992), Effects of various serotonin receptor subtype-selective antagonists alone and on m-chlorophenylpiperazine-induced neuroendocrine changes in rats; J. Pharmacol. Exp. Ther., 263 588
- Bagdy et al. (1992), Pharmacological characterization of serotonin receptor subtypes involved in vasopressin and plasma renin activity responses to serotonin agonists; Eur. J. Pharmacol., 210 285
- Knight et al. (2009), Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists; Mol. Pharmacol., 75 374
- Falsetti et al. (1982), Metergoline in the management of hyperprolactinemia amenorrhea and anovulation; Gynecol. Obstet. Invest., 13 108
- Turner et al. (2002), Double-blind, placebo-controlled study of single-dose metergoline in depressed patients with seasonal affective disorder; J. Clin. Psychopharmacol., 22 216
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