Methoprene Acid | Selective RXR agonist
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $70.00 | ||
| 25 mg | $280.00 |
Methoprene Acid (53093-52-7) is an analog of insect juvenile hormone which acts as an insect growth regulator. Binds directly and selectively to the retinoid X receptor (RXR) acting as a transcriptional activator in both insect and mammalian cells with no activity at RAR.1 Negatively regulates thrombosis and hemostasis.2 Induces neurosteroid biosynthesis in human glial GI-1 cells.3 Increases the expression of the brown-fat-uncoupling-protein-1 gene (ucp-1).4
References/Citations:
1) Harmon et al. (1995), Activation of mammalian retinoid X receptors by the insect growth regulator methoprene; Proc. Natl. Acad. Sci. USA, 92 6157
2) Unsworth et al. (2017), RXR Ligands Negatively Regulate Thrombosis and Hemostasis; Arterioscler. Thromb. Vasc. Biol., 37 812
3) Kushida and Tamura (2009), Retinoic acids induce neurosteroid biosynthesis in human glial GL-1 cells via the induction of steroidogenic genes; J. Biochem., 146 917
4) Alvarez et al. (2000), Both retinoic-acid-receptor and retinoid-X-receptor-dependent signaling pathways mediate the induction of the brown-adipose-tissue-uncoupling-protein-1 gene by retinoids; Biochem. J., 345 Pt 1 91
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Methoprene Acid (53093-52-7) is an analog of insect juvenile hormone which acts as an insect growth regulator. Binds directly and selectively to the retinoid X receptor (RXR) acting as a transcriptional activator in both insect and mammalian cells with no activity at RAR.1 Negatively regulates thrombosis and hemostasis.2 Induces neurosteroid biosynthesis in human glial GI-1 cells.3 Increases the expression of the brown-fat-uncoupling-protein-1 gene (ucp-1).4
References/Citations:
1) Harmon et al. (1995), Activation of mammalian retinoid X receptors by the insect growth regulator methoprene; Proc. Natl. Acad. Sci. USA, 92 6157
2) Unsworth et al. (2017), RXR Ligands Negatively Regulate Thrombosis and Hemostasis; Arterioscler. Thromb. Vasc. Biol., 37 812
3) Kushida and Tamura (2009), Retinoic acids induce neurosteroid biosynthesis in human glial GL-1 cells via the induction of steroidogenic genes; J. Biochem., 146 917
4) Alvarez et al. (2000), Both retinoic-acid-receptor and retinoid-X-receptor-dependent signaling pathways mediate the induction of the brown-adipose-tissue-uncoupling-protein-1 gene by retinoids; Biochem. J., 345 Pt 1 91
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