MF-438 | SCD1 inhibitor

CAS:
921605-87-0
Catalog Number:
10-4558
Activity:
SCD1 inhibitor
Chemical Name:
2-Methyl-5-(6-(4-(2-trifluoromethyl)phenoxy)piperidin-3-yl)-1,3,4-thiadiazole
Molecular Weight:
421.44
Molecular Formula:
C19H18F3N5OS
Solubility:
Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 2 mg/ml with warming).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Confirms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$60.00
25 mg$250.00
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MF-438 (921605-87-0) is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) – IC50 = 2.3 nM.1 MF-438 was potent in an in vivo mouse liver PD assay (ED50 between 1 and 3 mg/kg).1 Cancer initiating cells (CSC-like) were shown to be much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model.2 MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models.

References/Citations:

1) Leger et al. (2010), Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438); Bioorg. Med. Chem. Lett., 20 499
2) Noto et al. (2013), Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells; Cell Death and Differ., 4 e947
3) Rodriguez-Perez et al. (2017), Altered fatty acid metabolism and reduced stearoyl-coenzyme A desaturase activity in asthma; Allergy, 72 1744 [Citation]

CAS:
921605-87-0
Catalog Number:
10-4558
Activity:
SCD1 inhibitor
Chemical Name:
2-Methyl-5-(6-(4-(2-trifluoromethyl)phenoxy)piperidin-3-yl)-1,3,4-thiadiazole
Molecular Weight:
421.44
Molecular Formula:
C19H18F3N5OS
Solubility:
Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 2 mg/ml with warming).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Confirms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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