Size : | Price | Quantity | |
---|---|---|---|
5 mg | $60.00 | ||
25 mg | $250.00 |
MF-438 (921605-87-0) is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) – IC50 = 2.3 nM.1 MF-438 was potent in an in vivo mouse liver PD assay (ED50 between 1 and 3 mg/kg).1 Cancer initiating cells (CSC-like) were shown to be much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model.2 MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models.
References/Citations:
1) Leger et al. (2010), Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438); Bioorg. Med. Chem. Lett., 20 499
2) Noto et al. (2013), Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells; Cell Death and Differ., 4 e947
3) Rodriguez-Perez et al. (2017), Altered fatty acid metabolism and reduced stearoyl-coenzyme A desaturase activity in asthma; Allergy, 72 1744 [Citation]
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MF-438 (921605-87-0) is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) – IC50 = 2.3 nM.1 MF-438 was potent in an in vivo mouse liver PD assay (ED50 between 1 and 3 mg/kg).1 Cancer initiating cells (CSC-like) were shown to be much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model.2 MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models.
References/Citations:
1) Leger et al. (2010), Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438); Bioorg. Med. Chem. Lett., 20 499
2) Noto et al. (2013), Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells; Cell Death and Differ., 4 e947
3) Rodriguez-Perez et al. (2017), Altered fatty acid metabolism and reduced stearoyl-coenzyme A desaturase activity in asthma; Allergy, 72 1744 [Citation]
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