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Product Details

MF-438 | SCD1 inhibitor

MF-438 (921605-87-0) is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) - IC50 = 2.3 nM.1 MF-438 was potent in an in vivo mouse liver PD assay (ED50 between 1 and mg/kg).1 Cancer initiating cells (CSC-like) were shown to much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model.2 MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models.

References/Citations
1) Leger et al. (2010), Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438); Bioorg. Med. Chem. Lett., 20 499
2) Noto et al. (2013), Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells; Cell Death and Differ., 4 e947

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Catalog#  10-4558

$60.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
921605-87-0
Catalog Number:
10-4558
Activity:
SCD1 inhibitor
Chemical Name:
2-Methyl-5-(6-(4-(2-trifluoromethyl)phenoxy)piperidin-3-yl)-1,3,4-thiadiazole
Molecular Weight:
421.44
Molecular Formula:
C19H18F3N5OS
Solubility:
Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 2 mg/ml with warming).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Confirms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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