MG-132 | Proteasome inhibitor

CAS:
133407-82-6
Catalog Number:
10-1309
Activity:
Proteasome inhibitor
Alternate Names:
Z-Leu-Leu-Leu-CHO
Chemical Name:
N-(Benzyloxycarbonyl)leucinylleucinylleucinal
Molecular Weight:
475.63
Molecular Formula:
C26H41N3O5
Solubility:
Soluble in DMSO (up to 45 mg/ml), in DMF (up to 45 mg/ml), or in Ethanol (up to 45 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20° for up to 1 week.
Shipping Code:
RT

Available Options

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5 mg$50.00
25 mg$200.00
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MG-132 (133407-82-6) is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50=100 nM with Z-LLL-AMC as substrate).1 Also inhibits calpain (IC50=1.25 μM).1 Suppresses gastric cancer cell proliferation and induces macro-autophagy.2 Activates stress kinases and induces Hsp72.3 Induces neurite outgrowth.1 MG-132 blocks NFκB activation by blocking IκB proteolysis (IC50=3 μM).4 Cell permeable.

References/Citations:

1) Tsubuki et al. (1996), Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine; J. Biochem.,  119 572
2) Wu  et al. (2010), Macroautophagy and ERK phosphorylation counteract the antiproliferative effect of proteasome inhibitor in gastric cancer cells; Autophagy, 6 228
3) Meriin  et al. (1998), Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis; J. Biol. Chem., 273 6373
4) Fiedler et al. (1998), Inhibition of TNF-alpha-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132; Am. J. Respir. Cell Mol. Biol., 19 259

CAS:
133407-82-6
Catalog Number:
10-1309
Activity:
Proteasome inhibitor
Alternate Names:
Z-Leu-Leu-Leu-CHO
Chemical Name:
N-(Benzyloxycarbonyl)leucinylleucinylleucinal
Molecular Weight:
475.63
Molecular Formula:
C26H41N3O5
Solubility:
Soluble in DMSO (up to 45 mg/ml), in DMF (up to 45 mg/ml), or in Ethanol (up to 45 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20° for up to 1 week.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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