Microcystin LR | Protein phosphatase PP1 and PP2A inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 100 µg | $60.00 | ||
| 500 µg | $240.00 |
Microcystin LR (CAS 101043-37-2) is a novel freshwater cyanotoxin.1 Tumor promoter. Potent and selective inhibitor of protein phosphatase 2A (PP2A), IC50=0.04 nM. PP1, IC50=1.7 nM and PP2B are less sensitive and PP2C is not inhibited (up to 4 mM).2 Considered to be cell-impermeable with the exception of hepatocytes which take it up via an organic anion transporter.3
References/Citations:
1) Rinehart et al. (1988), Nodularin, microcystin, and the configuration of Adda; J. Am. Chem. Soc., 110 8557
2) Honkanen et al. (1990), Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases; J. Biol. Chem, 265 19401
3) Runnegar et al. (1995), Microcystin uptake and inhibition of protein phosphatases: effects of chemoprotectants and self-inhibition in relation to known hepatic transporters; Toxicol. Appl. Pharmacol., 134 264
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Microcystin LR (CAS 101043-37-2) is a novel freshwater cyanotoxin.1 Tumor promoter. Potent and selective inhibitor of protein phosphatase 2A (PP2A), IC50=0.04 nM. PP1, IC50=1.7 nM and PP2B are less sensitive and PP2C is not inhibited (up to 4 mM).2 Considered to be cell-impermeable with the exception of hepatocytes which take it up via an organic anion transporter.3
References/Citations:
1) Rinehart et al. (1988), Nodularin, microcystin, and the configuration of Adda; J. Am. Chem. Soc., 110 8557
2) Honkanen et al. (1990), Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases; J. Biol. Chem, 265 19401
3) Runnegar et al. (1995), Microcystin uptake and inhibition of protein phosphatases: effects of chemoprotectants and self-inhibition in relation to known hepatic transporters; Toxicol. Appl. Pharmacol., 134 264
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