Milbemectin | RDL GABA agonist and Glutamate-gated Cl channel activator
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 5mg | $110.00 | ||
| 25mg | $440.00 |
Milbemectin (1799297-76-9) is an allosteric agonist at the Drosophila RDL GABA receptor.1,2 Also acts as an agonist at glutamate-gated chloride channels in insects.3 Mutations (specifically a G326E substitution) in the glutamate-gated chloride channel 3 (GluCl3) in phytophagous mites abolishes agonist activity resulting in resistance.4 Commercially used as an acaricide.
Refences/Citations:
- Nakao et al. (2015), Comparison between the modes of action of novel meta-diamide and macrocyclic lactone insecticides on the RDL GABA receptor; Pestic. Biochem. Physiol., 120 101
- Casida and Durkin (2015), Novel GABA receptor pesticide targets; Pestic. Biochem. Physiol., 121 22
- Wolstenholme and Rogers (2005), Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics; Parasitology, 131 Suppl. S85
- Mermans et al. (2017), A G326E substitution in the glutamate-gated chloride channel 3 (GluCl3) of the two-spotted spider mite Tetranychus urticae abolishes the agnostic activity of macrocyclic lactones; Pest. Manag. Sci. 73 2413
Milbemycin A4: (6R,25R)-5-O-demethyl-28-deoxy-6,28-epoxy-25-ethyl-milbemycin B
C32H46O7 (A4)
>98% HPLC; Milbemectin is a mixture of Milbemycin A3 (~30%) and Milbemycin A4 (~70%)
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Milbemectin (1799297-76-9) is an allosteric agonist at the Drosophila RDL GABA receptor.1,2 Also acts as an agonist at glutamate-gated chloride channels in insects.3 Mutations (specifically a G326E substitution) in the glutamate-gated chloride channel 3 (GluCl3) in phytophagous mites abolishes agonist activity resulting in resistance.4 Commercially used as an acaricide.
Refences/Citations:
- Nakao et al. (2015), Comparison between the modes of action of novel meta-diamide and macrocyclic lactone insecticides on the RDL GABA receptor; Pestic. Biochem. Physiol., 120 101
- Casida and Durkin (2015), Novel GABA receptor pesticide targets; Pestic. Biochem. Physiol., 121 22
- Wolstenholme and Rogers (2005), Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics; Parasitology, 131 Suppl. S85
- Mermans et al. (2017), A G326E substitution in the glutamate-gated chloride channel 3 (GluCl3) of the two-spotted spider mite Tetranychus urticae abolishes the agnostic activity of macrocyclic lactones; Pest. Manag. Sci. 73 2413
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