Mirabegron | beta-3 Adrenergic agonist

CAS:
 223673-61-8
Catalog Number:
 10-4228
Mirabegron chemical structure Focus Biomolecules

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10 mg$50.00
50 mg$175.00

Mirabegron (223673-61-8) is a potent (EC50 = 22.4 nM CHO cells expressing human ß3-ARs) beta-3 adrenergic receptor (ß3-AR) agonist with high selectivity over the beta-1 and beta-2 receptors.1 Clinically useful for the treatment of overactive bladder syndrome. Chronic treatment of human subjects with mirabegron increased brown adipose tissue (BAT) metabolic activity, increased HDL and bile acid levels, and produced substantial improvements in glucose and insulin metabolism.2 Mirabegron inhibited tumor growth in various tumor models including pancreatic ductal adenocarcinoma and hepatocellular carcinoma via altering global metabolism in an uncoupling protein 1 (UCP1; a key protein for non-shivering thermogenesis) dependent manner.3

References/Citations:

  1. Takasu et al. (2007) Effect of (R)-2-(2-aminothiazol-4-yl)-4’-{2-[(2-hydroxy-2-phenylethyl)amino]ethyl}acetanilide (YM178), a novel selective beta3-adrenoceptor agonist, on bladder function; J. Pharmacol. Exp. Ther. 321 642
  2. O’Mara et al. (2020) Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity; J. Clin. Invest. 130 2209
  3. Sun et al. (2023) Mirabegron displays anticancer effects by globally browning adipose tissues; Nat. Commun. 14 7610
CAS:
223673-61-8
Catalog Number:
10-4228
Activity:
beta-3 Adrenergic agonist
Chemical Names:
2-(2-Amino-1,3-thiazol-4-yl)-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]acetamide
Alternate Name:
YM178
Molecular Weight:
396.51
Molecular Formula:

C21H24N4O2S

Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
Beige solid
Purity:

>98% by HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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