Mithramycin A | Transcription inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 1 mg | $42.00 | ||
| 5 mg | $165.00 |
Mithramycin A (18378-89-7) inhibits DNA methyl transferase.1 A selective Sp1 inhibitor, it binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, inhibiting their expression.2 Mithramycin A (at 10-200 nM) sensitizes tumor cells to TRAIL-induced apoptosis.3
References/Citations:
1) Lin et al. (2007), Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells; Anticancer Drugs, 18 1157
2) Jia et al. (2010), Combined treatment of pancreatic cancer cells with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic anti-tumor activity; Cancer Res., 70 1111
3) Lee et al. (2006), Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites; Mol. Cancer Ther., 5 2737
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Mithramycin A (18378-89-7) inhibits DNA methyl transferase.1 A selective Sp1 inhibitor, it binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, inhibiting their expression.2 Mithramycin A (at 10-200 nM) sensitizes tumor cells to TRAIL-induced apoptosis.3
References/Citations:
1) Lin et al. (2007), Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells; Anticancer Drugs, 18 1157
2) Jia et al. (2010), Combined treatment of pancreatic cancer cells with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic anti-tumor activity; Cancer Res., 70 1111
3) Lee et al. (2006), Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites; Mol. Cancer Ther., 5 2737
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