MiTMAB | Dynamin inhibitor

CAS:
1119-97-7
Catalog Number:
10-3051
Activity:
Dynamin inhibitor
Chemical Name:
Tetradecyltrimethylammonium bromide
Alternate Names:
Myristyltrimethylammonium bromide, MTAB, TTAB
Molecular Weight:
336.39
Molecular Formula:
C17H38BrN
Solubility:
Soluble in DMSO (up to 10 mg/ml), in Ethanol (up to 60 mg/ml) or in Water (up to 30 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol, or distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
10 mg$55.00
50 mg$180.00

MiTMAB (1119-97-7) is a dynamin I/II inhibitor targeting the dynamin-phospholipid interaction and inhibiting dynamin GTPase activity with a Ki=940nM.1 Rapidly and reversibly inhibits multiple forms of endocytosis with no acute cellular damage1. A useful pharmacological tool for studying dynamin-mediated trafficking events.2 Induces cytokinesis failure and apoptosis in human cancer cells.3 Induces cytoprotective autophagy in human Jurkat T cells.4

References/Citations:

1) Quan et al. (2007), Myristal trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecules dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II; Mol. Pharmacol., 72 1425
2) Joshi et al. (2011), Development and validation of a stability indicating method for the enantioselective estimation of omeprazole enantiomers in the enteric-coated formulations by high performance liquid chromatography; Mol. Cancer, 104 78
3) De Beco et al. (2009), Endocytosis is required for E-cadherin redistribution at mature adherens junctions; Proc. Natl. Acad. Sci. USA, 106 7010
4) Kim et al. (2016), Inhibition of autophagy enhances dynamin inhibitor-induced apoptosis via promoting Bak activation and mitochondrial damage in human Jurkat T cells; Biochem. Biophys. Res. Commun., 478 1609

CAS:
1119-97-7
Catalog Number:
10-3051
Activity:
Dynamin inhibitor
Chemical Name:
Tetradecyltrimethylammonium bromide
Alternate Names:
Myristyltrimethylammonium bromide, MTAB, TTAB
Molecular Weight:
336.39
Molecular Formula:
C17H38BrN
Solubility:
Soluble in DMSO (up to 10 mg/ml), in Ethanol (up to 60 mg/ml) or in Water (up to 30 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol, or distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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