Mito-lonidamine | Mitochondria-targeted antiglycolytic agent
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 5mg | $100.00 | ||
| 25mg | $400.00 |
Lonidamine is an antiglycolytic drug with limited efficacy.1,2 Mito-lonidamine (2361564-49-8) is lonidamine conjugated to a triphenylphosphonium moiety via a decyl-linker which is an effective mitochondria-targeting group.3 Mito-lonidamine was shown to be 100-fold more potent than lonidamine. It is a tumor-selective inhibitor of oxidative phosphorylation inhibiting mitochondrial bioenergetics in lung cancer cells and suppressing lung cancer cell viability, growth, progression and metastasis of lung cancer xenografts in mice.3
References/Citations:
- Paggi et al. (1998), Effect of lonidamine on human malignant gliomas: biochemical studies; Neurooncol., 6 203
- Guo et al. (2016), Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine; J. Biol. Chem., 291 42
- Cheng et al. (2019), Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis; Nat. Commun., 10 2205
C43H45BrCl2N3OP
>98% TLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Lonidamine is an antiglycolytic drug with limited efficacy.1,2 Mito-lonidamine (2361564-49-8) is lonidamine conjugated to a triphenylphosphonium moiety via a decyl-linker which is an effective mitochondria-targeting group.3 Mito-lonidamine was shown to be 100-fold more potent than lonidamine. It is a tumor-selective inhibitor of oxidative phosphorylation inhibiting mitochondrial bioenergetics in lung cancer cells and suppressing lung cancer cell viability, growth, progression and metastasis of lung cancer xenografts in mice.3
References/Citations:
- Paggi et al. (1998), Effect of lonidamine on human malignant gliomas: biochemical studies; Neurooncol., 6 203
- Guo et al. (2016), Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine; J. Biol. Chem., 291 42
- Cheng et al. (2019), Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis; Nat. Commun., 10 2205
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