Mito-Photo-DNP | Mitochondria specific, photo-activated protonophore
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 1 mg | $65.00 | ||
| 5 mg | $240.00 |
Mito-Photo-DNP is a mitochondria-targeted, photo-activated protonophore.1 This novel tool consists of three structural units, a caged protonophore, a photocleavable linker coupled to a triphenylphosphonium moiety which confers selective uptake by the mitochondria.2 Cells are treated with Mito-Photo-DNP at 200 nM and irradiated with UV light at 355 nm. Mito-Photo-DNP can be employed for selective uncoupling of either individual or a small number of mitochondria within a cell when used with fluorescence imaging.1,3
References/Citations:
1) Chalmers et al. (2012), Selective uncoupling of individual mitochondria within a cell using mitochondria-targeted photoactivated protonophore; J. Am. Chem.Soc., 134 758
2) Smith et al. (2012), Mitochondrial pharmacology; Trends Pharmacol. Sci., 33 341
3) Glancy et al. (2015), Mitochondrial reticulum for cellular energy distribution in muscle; Nature, 523 617
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Mito-Photo-DNP is a mitochondria-targeted, photo-activated protonophore.1 This novel tool consists of three structural units, a caged protonophore, a photocleavable linker coupled to a triphenylphosphonium moiety which confers selective uptake by the mitochondria.2 Cells are treated with Mito-Photo-DNP at 200 nM and irradiated with UV light at 355 nm. Mito-Photo-DNP can be employed for selective uncoupling of either individual or a small number of mitochondria within a cell when used with fluorescence imaging.1,3
References/Citations:
1) Chalmers et al. (2012), Selective uncoupling of individual mitochondria within a cell using mitochondria-targeted photoactivated protonophore; J. Am. Chem.Soc., 134 758
2) Smith et al. (2012), Mitochondrial pharmacology; Trends Pharmacol. Sci., 33 341
3) Glancy et al. (2015), Mitochondrial reticulum for cellular energy distribution in muscle; Nature, 523 617
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