MitoBloCK-10 | TIMM44 blocker
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $240.00 |
MitoBloCK-10 (394694-98-5) is a first in class TIMM44 blocker. Translocase of inner mitochondrial membrane 44 (TIMM44) is essential for maintaining function and integrity of mitochondria.1 It induced mitochondrial dysfunction and suppressed angiogenic activity in endothelial cells.1 Targeting TIMM44 by MitoBloCK-10 significantly inhibits bladder cancer cell growth in vitro and in vivo.2
References/Citations:
- Ma et al. (2023), The mitochondrial protein TIMM44 is required for angiogenesis in vitro and in vivo; Cell Death Dis. 14 307
- Zhang et al. (2024), A first-in-class TIMM44 blocker inhibits bladder cancer cell growth; Cell Death Dis. 15 204
C12H8FN3O3S
>98% TLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
MitoBloCK-10 (394694-98-5) is a first in class TIMM44 blocker. Translocase of inner mitochondrial membrane 44 (TIMM44) is essential for maintaining function and integrity of mitochondria.1 It induced mitochondrial dysfunction and suppressed angiogenic activity in endothelial cells.1 Targeting TIMM44 by MitoBloCK-10 significantly inhibits bladder cancer cell growth in vitro and in vivo.2
References/Citations:
- Ma et al. (2023), The mitochondrial protein TIMM44 is required for angiogenesis in vitro and in vivo; Cell Death Dis. 14 307
- Zhang et al. (2024), A first-in-class TIMM44 blocker inhibits bladder cancer cell growth; Cell Death Dis. 15 204
Related products
-
ML335 | TREK-1,2 activator
From $55.00CAS:825658-06-8Catalog Number:10-3648Activity:TREK-1,2 activatorChemical Name:N-(2,4-Dichlorobenzyl)-4-(methylsulfonamido)benzamideMolecular Weight:373.25Molecular Formula:C15H14Cl2N2O3SSolubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml with warming).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.Shipping Code:RT -
BI 2536 | Dual Plk/BRD4 inhibitor – Destabilizes Myc
From $75.00CAS:755038-02-9Catalog Number:10-4121Activity:Dual Plk/BRD4 inhibitor – Destabilizes MycChemical Name:4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamideMolecular Weight:521.67Molecular Formula:C28H39N7O3Solubility:Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 25 mg/ml)Physical Properties:Off-white solidPurity:97% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
NU7441 | DNA-PK inhibitor
From $50.00CAS:503468-95-9Catalog Number:10-4810Activity:DNA-PK inhibitorChemical Name:8-Dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-oneAlternate Name:Ku-57788Molecular Weight:413.49Molecular Formula:C25H19NO3SSolubility:Soluble in DMSO (up to 10 mg/ml with warming).Physical Properties:Off-white to beige solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
