Mizoribine | Immunosuppressant nucleoside

Mizoribine chemical structure

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Mizoribine (50924-49-7) is an immunosuppressant nucleoside natural product first isolated from Eupenicillium brefeldianum.1 Inhibits inosine monophosphate dehydrogenase, suppressing T-cell proliferation via depletion of guanine ribonucleotides.2 Reduces cellular GTP levels in CEM leukemia cells (68% at 4 mM and 2 hours).3 Selectively attenuates the expression of monocyte chemoattractant protein 1.4 Mizoribine also acts at HSP60, and induces an HSP60/HSP10 complex which consequently suppresses IL-6 expression.5 It displays anti-proteinuric effects by restoring normal nephrin biogenesis in nephrotic syndrome models.6

References/Citations:

  1. Ishikawa et al. (1999), Mizoribine and mycophenolate mofetil; Curr. Med. Chem., 6 575
  2. Dayton et al. (1992), Comparison of the effects of mizoribine with those of azathioprine, 6-mercaptopurine, and mycophenolic acid on T lymphocyte proliferation and purine ribonucleotide metabolism; Mol. Pharmacol., 41 671
  3. Catapano et al. (1995), GTP depletion induced by IMP dehydrogenase inhibitors blocks RNA-primed DNA synthesis; Mol.  Pharmacol., 6 575
  4. Aizawa et al. (2014), Mizoribine selectively attenuates monocyte chemoattractant protein-1 production in cultured human glomerular mesangial cell: a possible benefit of its use in the treatment of lupus nephritis; Nephrology (Cariton), 19 47
  5. Miura et al. (2024), Mizoribine Promotes Molecular Chaperone HSP60/HSP10 Complex Formation; Int. J. Mol. Sci., 25 6452
  6. Nakajo et al. (2007), Mizoribine corrects defective nephrin biogenesis by restoring intracellular energy balance; J. Am. Soc. Nephrol., 18 255
50924-49-7, mizoribine, Mizoribine supplier, NSC-289637
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NSC-289637

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Mizoribine (50924-49-7) is an immunosuppressant nucleoside natural product first isolated from Eupenicillium brefeldianum.1 Inhibits inosine monophosphate dehydrogenase, suppressing T-cell proliferation via depletion of guanine ribonucleotides.2 Reduces cellular GTP levels in CEM leukemia cells (68% at 4 mM and 2 hours).3 Selectively attenuates the expression of monocyte chemoattractant protein 1.4 Mizoribine also acts at HSP60, and induces an HSP60/HSP10 complex which consequently suppresses IL-6 expression.5 It displays anti-proteinuric effects by restoring normal nephrin biogenesis in nephrotic syndrome models.6

References/Citations:

  1. Ishikawa et al. (1999), Mizoribine and mycophenolate mofetil; Curr. Med. Chem., 6 575
  2. Dayton et al. (1992), Comparison of the effects of mizoribine with those of azathioprine, 6-mercaptopurine, and mycophenolic acid on T lymphocyte proliferation and purine ribonucleotide metabolism; Mol. Pharmacol., 41 671
  3. Catapano et al. (1995), GTP depletion induced by IMP dehydrogenase inhibitors blocks RNA-primed DNA synthesis; Mol.  Pharmacol., 6 575
  4. Aizawa et al. (2014), Mizoribine selectively attenuates monocyte chemoattractant protein-1 production in cultured human glomerular mesangial cell: a possible benefit of its use in the treatment of lupus nephritis; Nephrology (Cariton), 19 47
  5. Miura et al. (2024), Mizoribine Promotes Molecular Chaperone HSP60/HSP10 Complex Formation; Int. J. Mol. Sci., 25 6452
  6. Nakajo et al. (2007), Mizoribine corrects defective nephrin biogenesis by restoring intracellular energy balance; J. Am. Soc. Nephrol., 18 255