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MK-2206 | Potent and selective AKT inhibitor

MK-2206 (CAS 1032350-13-2) is a potent and selective allosteric inhibitor of Akt (IC50’s: Akt1 = 5 nM, Akt2 = 12 nM, Akt3 = 65 nM) that enhances the in vitro and in vivo antitumor efficacy of several standard chemotherapeutic agents.1 It was able to decrease insulin-stimulated glucose uptake, glycogen synthesis and glycogen synthase activity in rat muscle.2 MK-2206 induced G1-phase cycle arrest and sensitized HepG2 hepatocellular carcinoma cells to TRAIL-induced apoptosis.3

References/Citations

1) Hirai et al. (2010), MK-2206, an Allosteric Akt inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular targeted Drugs In vitro and In vivo; Mol. Cancer Ther. 9 1956
2) Lai et al. (2012), A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle; Biochem. J. 447 137
3) Jiao et al. (2013), MK-2206 induces cell cycle arrest and apoptosis in HepG2 cells and sensitizes TRAIL-mediated cell death; Mol. Cell Biochem. 382 217

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Focus Biomolecules cell signaling reagent supplier, chemical structure of MK-2206 | Akt inhibitor | CAS 1032350-13-2

Catalog#  10-4801-0005

$70.00
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CAS:
1032350-13-2
Catalog Number:
10-4801
Activity:
Potent and selective AKT inhibitor
Chemical Name:
8-(4-(1-Aminocyclobutyl)phenyl-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one dihydrochloride
Molecular Weight:
480.39
Molecular Formula:
C25H21N5O • 2HCl
Solubility:
Soluble in DMSO (up to 10 mg/ml with warming)
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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