MK-571 | Cys LT1 antagonist
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $240.00 |
MK-571 (115104-28-4) is a potent (EC50 = 1.3nM) and selective Leukotriene D4 antagonist (LTD4)1 displaying inverse agonist activity2. Blocks binding of LTD4 to human (Ki = 0.22 nM) and guinea pig (Ki = 2.1 nM) lung membranes. Selective for the CysLT1 receptor. MK-571 is also a multidrug resistance protein 1 (MRP1) inhibitor.3
References/Citations:
1) Jones et al. (1989) Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist.; Can. J. Physiol. Pharmacol. 67, 17
2) Dupre et al. (2004) Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1; J. Pharmacol. Exp. Ther. 309 102
3) Vellenga et al. (1999) Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1; Br .J. Pharmacol. 127 441
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
MK-571 (115104-28-4) is a potent (EC50 = 1.3nM) and selective Leukotriene D4 antagonist (LTD4)1 displaying inverse agonist activity2. Blocks binding of LTD4 to human (Ki = 0.22 nM) and guinea pig (Ki = 2.1 nM) lung membranes. Selective for the CysLT1 receptor. MK-571 is also a multidrug resistance protein 1 (MRP1) inhibitor.3
References/Citations:
1) Jones et al. (1989) Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist.; Can. J. Physiol. Pharmacol. 67, 17
2) Dupre et al. (2004) Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1; J. Pharmacol. Exp. Ther. 309 102
3) Vellenga et al. (1999) Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1; Br .J. Pharmacol. 127 441
Related products
-
LY171883 | Cys LT1 antagonist
From $60.00CAS:88107-10-2Catalog Number:10-1052Activity:Cys LT1 antagonistChemical Name:1-[2-Hydroxy-3-propyl-4-[4-1H-tetrazol-5-yl)butoxy]phenyl]ethanoneMolecular Weight:318.37Molecular Formula:C16H22N4O3Solubility:Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml),Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°C (des.)Stability:Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 monthsShipping Code:RT -
JZL-184 | MAG lipase inhibitor
From $62.00CAS:1101854-58-3Catalog Number:10-1021Activity:MAG lipase inhibitorChemical Name:4-Nitrophenyl-4-(dibenzo[d][1,3]dioxol-5-yl(hydroxyl)methyl)piperidine-1-carboxylateMolecular Weight:520.5Molecular Formula:C27H24N2O9Solubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:Light yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 monthsShipping Code:RT -
JNJ-1661010 | FAAH inhibitor
From $80.00CAS:681136-29-8Catalog Number:10-1298Activity:FAAH inhibitorAlternate Names:N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamideChemical Name:4-(3-Phenyl-[1,2,4]thizdiazol-5-yl)-piperazine-1-carboxylic acid phenylamideMolecular Weight:365.46Molecular Formula:C19H19N5OSSolubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:Off-white solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
