ML204 | TRPC4 blocker
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $200.00 |
ML204 (5485-86-1) is a selective blocker of TRPC4 channels (IC50 = 0.96 – 2.6 μM, depending on assay). Displays 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5. Has no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM. A useful tool for exploring the involvement of TRPC and TRPC-like channels in cellular signaling and physiology.2-4
References/Citations:
1) Miller et al. (2011), Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels; J. Biol. Chem., 286 33436
2) Zhang et al. (2013), GIRK-like and TRPC-like conductances mediate thyrotropin-releasing hormone-induced increases in excitability in thalamic paraventricular nucleus neurons; Neuropharmacology, 72 106
3) Zhang et al. (2016), Endocannabinoid 2-AG and intracellular cannabinoid receptors modulate a low-threshold calcium spike-induced slow depolarizing afterpotential in rat thalamic paraventricular nucleus neurons; Neuroscience, 322 308
4) Zhao et al. (2015), TRP Channels Localize to Subdomains of the Apical Plasma Membrane in Human Fetal Retinal Pigment Epithelium; Invest. Ophthalmol. Vis. Sci., 56 1916
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
ML204 (5485-86-1) is a selective blocker of TRPC4 channels (IC50 = 0.96 – 2.6 μM, depending on assay). Displays 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5. Has no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM. A useful tool for exploring the involvement of TRPC and TRPC-like channels in cellular signaling and physiology.2-4
References/Citations:
1) Miller et al. (2011), Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels; J. Biol. Chem., 286 33436
2) Zhang et al. (2013), GIRK-like and TRPC-like conductances mediate thyrotropin-releasing hormone-induced increases in excitability in thalamic paraventricular nucleus neurons; Neuropharmacology, 72 106
3) Zhang et al. (2016), Endocannabinoid 2-AG and intracellular cannabinoid receptors modulate a low-threshold calcium spike-induced slow depolarizing afterpotential in rat thalamic paraventricular nucleus neurons; Neuroscience, 322 308
4) Zhao et al. (2015), TRP Channels Localize to Subdomains of the Apical Plasma Membrane in Human Fetal Retinal Pigment Epithelium; Invest. Ophthalmol. Vis. Sci., 56 1916
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