ML-792 | SUMO-activating enzyme inhibitor
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 5mg | $95.00 | ||
| 25mg | $350.00 |
ML-792 (1644342-14-2) is a potent (IC50’s = 3 nM SUMO1; 11 nM SUMO2) and selective ( IC50 = 32 µM for NEDD8-activating enzyme (NAE)) mechanism-based inhibitor of SUMO-activating enzyme (SAE).1 Treatment of multiple cancer cell lines led to failure of mitotic progression and induction of endoreduplication with MYC-amplified cell lines showing higher sensitivity. ML-792 inhibited B-cell growth and promoted cell death in Epstein-Barr virus (EBV)-positive B cells and nasopharyngeal carcinoma cells. It also modulated Latent Membrane Protein-1-induced cell migration and cell adhesion suggesting therapeutic potential in treating EBV-associated malignancies.2
References/Citations:
- He et al. (2017), Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor; Nat. Chem. Biol. 13 1164
- Garcia et al. (2021); Effects of targeting sumoylation processes during latent and induced Epstein-Barr virus infections using the small molecules inhibitor ML-792, Antiviral Res., 188 105038
C21H23BrN6O5S
>98% HPLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
ML-792 (1644342-14-2) is a potent (IC50’s = 3 nM SUMO1; 11 nM SUMO2) and selective ( IC50 = 32 µM for NEDD8-activating enzyme (NAE)) mechanism-based inhibitor of SUMO-activating enzyme (SAE).1 Treatment of multiple cancer cell lines led to failure of mitotic progression and induction of endoreduplication with MYC-amplified cell lines showing higher sensitivity. ML-792 inhibited B-cell growth and promoted cell death in Epstein-Barr virus (EBV)-positive B cells and nasopharyngeal carcinoma cells. It also modulated Latent Membrane Protein-1-induced cell migration and cell adhesion suggesting therapeutic potential in treating EBV-associated malignancies.2
References/Citations:
- He et al. (2017), Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor; Nat. Chem. Biol. 13 1164
- Garcia et al. (2021); Effects of targeting sumoylation processes during latent and induced Epstein-Barr virus infections using the small molecules inhibitor ML-792, Antiviral Res., 188 105038
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