ML210 | GPX4 inhibitor / Ferroptosis inducer
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $85.00 | ||
| 50 mg | $290.00 |
ML210 (CAS 1360705-96-9) is selectively synthetic lethal to HRAS expressing cells compared to isogenic non-HRAS cells (IC50 = 7.1 nM for BJeLR (expressing HRASg12v) cells vs IC50 = 272 nM for BJeH-LT (non-HRAS expressing) cells.1 ML210 is able to inhibit glutathione peroxidase 4 (GPX4), an important selenoenzyme that protects cells from ferroptosis caused by iron catalyzed formation of free radicals from lipid peroxides.2,3 Treatment of several treatment-resistant cancer cell lines exhibiting a high mesenchymal state with ML210 resulted in selective induction of ferroptosis.3
References/Citations:
1) Weiwer et al. (2012), Development of small-molecule probes that selectively kill cells induced to express mutant RAS; Bioorg. Med. Chem. Lett. 22 1822
2) Yang et al. (2014), Regulation of Ferroptotic Cancer Cell Death by GPX4; Cell 156 317
3) Viswanathan et al. (2017), Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway; Nature 547 453
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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ML210 (CAS 1360705-96-9) is selectively synthetic lethal to HRAS expressing cells compared to isogenic non-HRAS cells (IC50 = 7.1 nM for BJeLR (expressing HRASg12v) cells vs IC50 = 272 nM for BJeH-LT (non-HRAS expressing) cells.1 ML210 is able to inhibit glutathione peroxidase 4 (GPX4), an important selenoenzyme that protects cells from ferroptosis caused by iron catalyzed formation of free radicals from lipid peroxides.2,3 Treatment of several treatment-resistant cancer cell lines exhibiting a high mesenchymal state with ML210 resulted in selective induction of ferroptosis.3
References/Citations:
1) Weiwer et al. (2012), Development of small-molecule probes that selectively kill cells induced to express mutant RAS; Bioorg. Med. Chem. Lett. 22 1822
2) Yang et al. (2014), Regulation of Ferroptotic Cancer Cell Death by GPX4; Cell 156 317
3) Viswanathan et al. (2017), Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway; Nature 547 453
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