ML210 | GPX4 inhibitor / Ferroptosis inducer

CAS:
1360705-96-9
Catalog Number:
10-4002
Activity:
GPX4 inhibitor / Ferroptosis inducer
Chemical Name:
(4-(Bis(4-chlorophenyl)methyl)piperazine-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone
Molecular Weight:
475.32
Molecular Formula:
C22H20Cl2N4O4
Solubility:
Soluble in DMSO (up to 30 mg/ml)
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
10 mg$85.00
50 mg$290.00

ML210 (CAS 1360705-96-9) is selectively synthetic lethal to HRAS expressing cells compared to isogenic non-HRAS cells (IC50 = 7.1 nM for BJeLR (expressing HRASg12v) cells vs IC50 = 272 nM for BJeH-LT (non-HRAS expressing) cells.1 ML210 is able to inhibit glutathione peroxidase 4 (GPX4), an important selenoenzyme that protects cells from ferroptosis caused by iron catalyzed formation of free radicals from lipid peroxides.2,3 Treatment of several treatment-resistant cancer cell lines exhibiting a high mesenchymal state with ML210 resulted in selective induction of ferroptosis.3

References/Citations:

1) Weiwer et al. (2012), Development of small-molecule probes that selectively kill cells induced to express mutant RAS; Bioorg. Med. Chem. Lett. 22 1822
2) Yang et al. (2014), Regulation of Ferroptotic Cancer Cell Death by GPX4; Cell 156 317
3) Viswanathan et al. (2017), Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway; Nature 547 453

CAS:
1360705-96-9
Catalog Number:
10-4002
Activity:
GPX4 inhibitor / Ferroptosis inducer
Chemical Name:
(4-(Bis(4-chlorophenyl)methyl)piperazine-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone
Molecular Weight:
475.32
Molecular Formula:
C22H20Cl2N4O4
Solubility:
Soluble in DMSO (up to 30 mg/ml)
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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