ML277 | Potent Kv7.1 activator
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $220.00 |
ML277 (1401242-74-7) is a potent (EC50 = 260 nM) activator of Kv7.1 with selectivity against Kv7.2, Kv7.4, and Kv11.1 (hERG).1 ML277 enhances cardiac delayed rectifier K+ currents (IKs) in human iPSC-derived cardiomyocytes from normal and long QT-interval syndrome afflicted patients suggesting potential therapeutic use in long QT-interval syndrome.2,3 It displayed cardioprotective effects against ischemia in cellular and whole-heart models.4
References/Citations:
- Mattman et al. (2012) Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent, and selective K(v)7.1(KCNQ1 potassium channel activator; Bioorg. Med. Chem. Lett. 22 5936
- Yu et al. (2013) Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels; Proc. Nat. Acad. Sci. USA 110 8732
- Ma et al. (2015) Characterization of a novel KCNQ1 mutation for type 1 long QT syndrome and assessment of the therapeutic potential of a novel IKs activator using patient-specific induced pluripotent stem cell-derived cardiomyocytes; Stem Cell Res. Ther. 6 39
- Brennan et al. (2023) Slowly activating voltage-gated potassium current potentiation by ML277 is a novel cardioprotective intervention; PNAS Nexus 2 pgad156
C23H25N3O4S2
>98% by HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
ML277 (1401242-74-7) is a potent (EC50 = 260 nM) activator of Kv7.1 with selectivity against Kv7.2, Kv7.4, and Kv11.1 (hERG).1 ML277 enhances cardiac delayed rectifier K+ currents (IKs) in human iPSC-derived cardiomyocytes from normal and long QT-interval syndrome afflicted patients suggesting potential therapeutic use in long QT-interval syndrome.2,3 It displayed cardioprotective effects against ischemia in cellular and whole-heart models.4
References/Citations:
- Mattman et al. (2012) Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent, and selective K(v)7.1(KCNQ1 potassium channel activator; Bioorg. Med. Chem. Lett. 22 5936
- Yu et al. (2013) Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels; Proc. Nat. Acad. Sci. USA 110 8732
- Ma et al. (2015) Characterization of a novel KCNQ1 mutation for type 1 long QT syndrome and assessment of the therapeutic potential of a novel IKs activator using patient-specific induced pluripotent stem cell-derived cardiomyocytes; Stem Cell Res. Ther. 6 39
- Brennan et al. (2023) Slowly activating voltage-gated potassium current potentiation by ML277 is a novel cardioprotective intervention; PNAS Nexus 2 pgad156
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