ML335 | TREK-1,2 activator
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $55.00 | ||
| 25 mg | $220.00 |
Two-pore domain potassium (K2P) channels of the TREK subfamily regulate neuronal excitability, influence pain, temperature perception and responses to anesthetics. ML-335 (825658-06-8) is a novel, selective TREK-1,2 activator with EC50s of 14.3 and 5.2 μM.1 It represents an important new pharmacological tool for studying the physiology of TREK channels.
References/Citations:
1) Lolicato et al. (2017), K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site; Nature, 547 364
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Two-pore domain potassium (K2P) channels of the TREK subfamily regulate neuronal excitability, influence pain, temperature perception and responses to anesthetics. ML-335 (825658-06-8) is a novel, selective TREK-1,2 activator with EC50s of 14.3 and 5.2 μM.1 It represents an important new pharmacological tool for studying the physiology of TREK channels.
References/Citations:
1) Lolicato et al. (2017), K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site; Nature, 547 364
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