ML335 | TREK-1,2 activator

CAS:
825658-06-8
Catalog Number:
10-3648
Activity:
TREK-1,2 activator
Chemical Name:
N-(2,4-Dichlorobenzyl)-4-(methylsulfonamido)benzamide
Molecular Weight:
373.25
Molecular Formula:
C15H14Cl2N2O3S
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$55.00
25 mg$220.00

Two-pore domain potassium (K2P) channels of the TREK subfamily regulate neuronal excitability, influence pain, temperature perception and responses to anesthetics. ML-335 (825658-06-8) is a novel, selective TREK-1,2 activator with EC50s of 14.3 and 5.2 μM.1 It represents an important new pharmacological tool for studying the physiology of TREK channels.

References/Citations:

1) Lolicato et al. (2017), K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site; Nature, 547 364

CAS:
825658-06-8
Catalog Number:
10-3648
Activity:
TREK-1,2 activator
Chemical Name:
N-(2,4-Dichlorobenzyl)-4-(methylsulfonamido)benzamide
Molecular Weight:
373.25
Molecular Formula:
C15H14Cl2N2O3S
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

20% OFF

For Postdoc
Customers!