Size: | Price | Quantity | |
---|---|---|---|
5 mg | $55.00 | ||
25 mg | $220.00 |
Two-pore domain potassium (K2P) channels of the TREK subfamily regulate neuronal excitability, influence pain, temperature perception and responses to anesthetics. ML-335 (825658-06-8) is a novel, selective TREK-1,2 activator with EC50s of 14.3 and 5.2 μM.1 It represents an important new pharmacological tool for studying the physiology of TREK channels.
References/Citations:
1) Lolicato et al. (2017), K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site; Nature, 547 364
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Two-pore domain potassium (K2P) channels of the TREK subfamily regulate neuronal excitability, influence pain, temperature perception and responses to anesthetics. ML-335 (825658-06-8) is a novel, selective TREK-1,2 activator with EC50s of 14.3 and 5.2 μM.1 It represents an important new pharmacological tool for studying the physiology of TREK channels.
References/Citations:
1) Lolicato et al. (2017), K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site; Nature, 547 364
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