ML418 | Kir7.1/6.2 blocker

CAS:
 1928763-08-9
Catalog Number:
 10-4652
ML418 chemical structure Focus Biomolecules

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5 mg$70.00
25 mg$225.00

ML418 (1928763-08-9) is a blocker of the inward rectifier potassium channels Kir7.1 (IC50 = 310nM) and Kir6.2 (equipotent) with metabolic and pharmacokinetic parameters suitable for in vivo research.1 Greater than 23-fold selectivity over Kir1.1, Kir2.1, Kir2.2, Kir2.3, Kir4.1.

References/Citations:

  1. Swale et al. (2016), ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels; ACS Chem. Neurosci. 7 1013
CAS:
1928763-08-9
Catalog Number:
10-4652
Activity:
Kir7.1/6.2 blocker
Chemical Names:
Isopropyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl)piperidin-4-yl)carbamate
Molecular Weight:
377.87
Molecular Formula:

C19H24ClN3O3

Solubility:
Soluble in DMSO (8 mg/ml with warming)
Physical Properties:
White solid
Purity:

>98% by HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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