ML60218 | RNA Polymerase III inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $90.00 | ||
| 25 mg | $360.00 |
ML60218 (CAS 577784-91-9) is a broad spectrum inhibitor of RNA polymerase III from S. Cerevisiae as well as from human cells, IC50=32 mM and 27 mM respectively.1 Combined treatment with ML-60218 and an HDAC inhibitor caused augmented suppression of colony formation, induction of cell cycle arrest and apoptotic cell death in human pancreatic adenocarcinoma cells.2
References/Citations:
1) Wu et al. (2003), Novel small-molecule inhibitors of RNA polymerase III; Eukaryot. Cell, 2 256
2) Yee et al. (2012), Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer; Biol. Open, 1(4) 295
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
ML60218 (CAS 577784-91-9) is a broad spectrum inhibitor of RNA polymerase III from S. Cerevisiae as well as from human cells, IC50=32 mM and 27 mM respectively.1 Combined treatment with ML-60218 and an HDAC inhibitor caused augmented suppression of colony formation, induction of cell cycle arrest and apoptotic cell death in human pancreatic adenocarcinoma cells.2
References/Citations:
1) Wu et al. (2003), Novel small-molecule inhibitors of RNA polymerase III; Eukaryot. Cell, 2 256
2) Yee et al. (2012), Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer; Biol. Open, 1(4) 295
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