MLS-544460 | Eya2 phosphatase inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $220.00 |
MLS-544460 (352336-36-8) is an allosteric inhibitor of the Eya2 tyrosine phosphatase (IC50=4.1 µM)1-2 which is ineffective against other tyrosine phosphatases including Eya3 and PTP1B. Treatment of patient-derived glioma stem cells induced loss of bipolar spindle formation along with G2/M cell cycle arrest. GSC proliferation was inhibited at concentrations 4 to 10-fold lower than normal brain cells.3 Treatment of Axolotls following amputation impairs limb regeneration indicating a role for Eya2 in vertebrate regeneration.4
References/Citations:
- Kreuger et al. (2014), Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration; J. Biol. Chem. 289 16349
- Kreuger et al. (2013), Identification of a selective small-molecule inhibitor series targeting the eyes absent 2 (Eya2) phosphatase activity; J. Biomol. Screen. 18 85
- Zhang et al. (2021), Targeting EYA2 tyrosine phosphatase activity in glioblastoma stem cells induces mitotic catastrophe; J. Exp. Med. 218 e20202669
- Sousounis et al. (2020), Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration; Elife 289 e51217
C17H12FN3O2S
>98% TLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
MLS-544460 (352336-36-8) is an allosteric inhibitor of the Eya2 tyrosine phosphatase (IC50=4.1 µM)1-2 which is ineffective against other tyrosine phosphatases including Eya3 and PTP1B. Treatment of patient-derived glioma stem cells induced loss of bipolar spindle formation along with G2/M cell cycle arrest. GSC proliferation was inhibited at concentrations 4 to 10-fold lower than normal brain cells.3 Treatment of Axolotls following amputation impairs limb regeneration indicating a role for Eya2 in vertebrate regeneration.4
References/Citations:
- Kreuger et al. (2014), Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration; J. Biol. Chem. 289 16349
- Kreuger et al. (2013), Identification of a selective small-molecule inhibitor series targeting the eyes absent 2 (Eya2) phosphatase activity; J. Biomol. Screen. 18 85
- Zhang et al. (2021), Targeting EYA2 tyrosine phosphatase activity in glioblastoma stem cells induces mitotic catastrophe; J. Exp. Med. 218 e20202669
- Sousounis et al. (2020), Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration; Elife 289 e51217
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