Monensin Na | Golgi transport inhibitor
CAS:
22373-78-0
Catalog Number:
10-2659
Activity:
Golgi transport inhibitor
Chemical Names:
2-[5-Ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-hydroxymethyl-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β-methoxy-α,γ,2,8-tetramethyl-1,6-dioxaspiro[4.5]decane-7-butyric acid, sodium salt
Alternate Name:
NSC-343257
Molecular Weight:
692.86
Molecular Formula:
C36H61O11·Na
Solubility:
Soluble in DMSO (25 mg/ml with warming)
Physical Properties:
White solid
Purity:
90-95% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 1 g | $45.00 | ||
| 5 g | $200.00 |
Monensin (22373-78-0) is a monovalent-selective ionophore antibiotic, typically employed as a Na+ ionophore.1 Interferes with vesicular transport through the Golgi aparatus2 and induces Golgi swelling3. Neutralizes intracellular compartments such as the trans Golgi apparatus cisternae, lysosomes, and certain endosomes4 (inducing EGFR endosomal arrest for example5). Induces the cleavage of full-length CREB3 in HEK293 cells.6
References/Citations:
- Aowicki and Huczynski (2013), Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements; Res. Int. 2013 742149
- Kallen et al. (1993), Monensin inhibits synthesis of plasma membrane sphingomyelin by blocking transport of ceramide through the Golgi: evidence for two sites of sphingomyelin synthesis in BHK cells; Biophys. Acta 1166 305
- Boss et al. (1984), Monensin-induced swelling of Golgi apparatus cisternae mediated by a proton gradient; J. Cell. Biol. 34 1
- Mollenhauer et al. (1990), Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity; Biophys. Acta 1031 225
- Hafner et al. (2021), The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells; Pharmacol. 12 611657
- Oh-Hashi et al. (2021), Comparative Analysis of CREB3 and CREB3L2 Protein Expression in HEK293 Cells; J. Mol. Sci. 22 2767
CAS:
22373-78-0
Catalog Number:
10-2659
Activity:
Golgi transport inhibitor
Chemical Names:
2-[5-Ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-hydroxymethyl-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β-methoxy-α,γ,2,8-tetramethyl-1,6-dioxaspiro[4.5]decane-7-butyric acid, sodium salt
Alternate Name:
NSC-343257
Molecular Weight:
692.86
Molecular Formula:
C36H61O11·Na
Solubility:
Soluble in DMSO (25 mg/ml with warming)
Physical Properties:
White solid
Purity:
90-95% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Monensin (22373-78-0) is a monovalent-selective ionophore antibiotic, typically employed as a Na+ ionophore.1 Interferes with vesicular transport through the Golgi aparatus2 and induces Golgi swelling3. Neutralizes intracellular compartments such as the trans Golgi apparatus cisternae, lysosomes, and certain endosomes4 (inducing EGFR endosomal arrest for example5). Induces the cleavage of full-length CREB3 in HEK293 cells.6
References/Citations:
- Aowicki and Huczynski (2013), Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements; Res. Int. 2013 742149
- Kallen et al. (1993), Monensin inhibits synthesis of plasma membrane sphingomyelin by blocking transport of ceramide through the Golgi: evidence for two sites of sphingomyelin synthesis in BHK cells; Biophys. Acta 1166 305
- Boss et al. (1984), Monensin-induced swelling of Golgi apparatus cisternae mediated by a proton gradient; J. Cell. Biol. 34 1
- Mollenhauer et al. (1990), Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity; Biophys. Acta 1031 225
- Hafner et al. (2021), The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells; Pharmacol. 12 611657
- Oh-Hashi et al. (2021), Comparative Analysis of CREB3 and CREB3L2 Protein Expression in HEK293 Cells; J. Mol. Sci. 22 2767
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