MoTP | Induces melanocyte ablation
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $200.00 |
MoTP (57055-82-0) specifically ablates zebrafish larval melanocytes. Melanocytotoxicity is dependent on tyrosinase activity.1,2 MoTP is a useful tool for elucidating melanocyte stem cell regeneration, recruitment and maintenance.3-5
References/Citations:
1) Yang et al. (2006), Small molecule-induced ablation and subsequent regeneration of larval zebrafish melanocytes; Development, 133 3563
2) Yang et al. (2007), Mutations in gfpt1 and skiv2I2 cause distinct stage-specific defects in larval melanocyte regeneration in zebrafish; PLoS Genet., 3 e88
3) Hultman et al. (2009), Defects in ErbB-dependent establishment of adult melanocyte stem cells reveal independent origins for embryonic and regeneration melanocytes; PLoS Genet., 5 e1000544
4) Hultman et al. (2010), Differential contribution of direct-developing and stem cell-derived melanocytes to the zebrafish larval pigment pattern; Dev. Biol., 337 425
5) Hultman et al. (2008), Small molecule modifier screen for kit-dependent functions in zebrafish embryonic melanocytes; Zebrafish, 5 279
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
MoTP (57055-82-0) specifically ablates zebrafish larval melanocytes. Melanocytotoxicity is dependent on tyrosinase activity.1,2 MoTP is a useful tool for elucidating melanocyte stem cell regeneration, recruitment and maintenance.3-5
References/Citations:
1) Yang et al. (2006), Small molecule-induced ablation and subsequent regeneration of larval zebrafish melanocytes; Development, 133 3563
2) Yang et al. (2007), Mutations in gfpt1 and skiv2I2 cause distinct stage-specific defects in larval melanocyte regeneration in zebrafish; PLoS Genet., 3 e88
3) Hultman et al. (2009), Defects in ErbB-dependent establishment of adult melanocyte stem cells reveal independent origins for embryonic and regeneration melanocytes; PLoS Genet., 5 e1000544
4) Hultman et al. (2010), Differential contribution of direct-developing and stem cell-derived melanocytes to the zebrafish larval pigment pattern; Dev. Biol., 337 425
5) Hultman et al. (2008), Small molecule modifier screen for kit-dependent functions in zebrafish embryonic melanocytes; Zebrafish, 5 279
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