MreB Inhibitor A22 | Disrupts bacterial actin cytoskeleton
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $52.00 | ||
| 50 mg | $175.00 |
A22 (22816-60-0) disrupts the actin cytoskeleton of bacteria causing defects in morphology and chromosome segregation.1 It is a competitive inhibitor of ATP binding to MreB and has the ability to disassemble the actin cytoskeleton in bacterial cells.1 It displays antibacterial activity against P. aeruginosa (among many others) including multidrug-resistant clinical isolates and points to MreB as a new target for antibacterial development.2 A22 significantly disrupts biofilm formation by interfering with the ability of bacterial cells to maintain shape and adherence to surfaces.3
References/Citations:
- Bean et al. (2009), A22 disrupts the bacterial actin cytoskeleton by directly binding and inducing a low-affinity state in MreB; Biochemistry 48 4852
- Bonez et al. (2016), Antibacterial, cyto and genotoxic activities of A22 compound ((S-3, 4 -dichlorobenzyl) isothiourea hydrochloride); Microb. Pathog. 99 14
- Dardaei et al. (2017), Anti-biofilm activity of A22 ((S-3,4-dichlorobenzyl) isothiourea hydrochloride) against Pseudomonas aeruginosa: Influence on biofilm formation, motility and bioadhesion; Microb. Pathog. 111 6
C8H8Cl2N2S·HCl
>98% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
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A22 (22816-60-0) disrupts the actin cytoskeleton of bacteria causing defects in morphology and chromosome segregation.1 It is a competitive inhibitor of ATP binding to MreB and has the ability to disassemble the actin cytoskeleton in bacterial cells.1 It displays antibacterial activity against P. aeruginosa (among many others) including multidrug-resistant clinical isolates and points to MreB as a new target for antibacterial development.2 A22 significantly disrupts biofilm formation by interfering with the ability of bacterial cells to maintain shape and adherence to surfaces.3
References/Citations:
- Bean et al. (2009), A22 disrupts the bacterial actin cytoskeleton by directly binding and inducing a low-affinity state in MreB; Biochemistry 48 4852
- Bonez et al. (2016), Antibacterial, cyto and genotoxic activities of A22 compound ((S-3, 4 -dichlorobenzyl) isothiourea hydrochloride); Microb. Pathog. 99 14
- Dardaei et al. (2017), Anti-biofilm activity of A22 ((S-3,4-dichlorobenzyl) isothiourea hydrochloride) against Pseudomonas aeruginosa: Influence on biofilm formation, motility and bioadhesion; Microb. Pathog. 111 6
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