MS012 | Potent and selective GLP lysine methyltransferase inhibitor

CAS:
2089617-83-2
Catalog Number:
10-4875
Activity:
Potent and selective GLP lysine methyltransferase inhibitor
Chemical Names:
N2-Hexyl-6,7-dimethoxy-N4-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine
Molecular Weight:
401.55
Molecular Formula:
C22H35N5O2
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$75.00
25 mg$250.00

MS012 (2089617-83-2) is a highly potent (IC50 = 7 nM) and selective (140-fold over the related lysine methyltransferase G9a) inhibitor of G9a-Like Protein (GLP) Lysine Methyltransferase.  It was also selective for GLP over a panel of 29 other methyltransferases.

References/Citations:

  1. Xiong et al. (2017) Discovery of Potent and selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase; J. Med.Chem. 60 1876
CAS:
2089617-83-2
Catalog Number:
10-4875
Activity:
Potent and selective GLP lysine methyltransferase inhibitor
Chemical Names:
N2-Hexyl-6,7-dimethoxy-N4-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine
Molecular Weight:
401.55
Molecular Formula:
C22H35N5O2
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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