MU1700 | Selective ALK1/2 inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $95.00 | ||
| 25 mg | $310.00 |
MU1700 dihydrochloride (1360905-04-9 free base) is a potent (IC50’s = 13 nM ALK1; 6 nM ALK2) and highly selective (selective against 369 kinases with only ALK6 (41 nM) being inhibited) ALK1/2 inhibitor. Much higher kinome selectivity than the typically used ALK 1/2 inhibitor LDN-193189. MU1700 exhibits favorable pharmacokinetic and bioavailability profiles for in vivo use. It showed excellent CNS penetration with brain concentrations exceeding that in plasma.
References/Citations:
- Nemec et al. (2024), Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2; J.Med.Chem. 67 12632
C26H22N4O·2HCl
>98% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
MU1700 dihydrochloride (1360905-04-9 free base) is a potent (IC50’s = 13 nM ALK1; 6 nM ALK2) and highly selective (selective against 369 kinases with only ALK6 (41 nM) being inhibited) ALK1/2 inhibitor. Much higher kinome selectivity than the typically used ALK 1/2 inhibitor LDN-193189. MU1700 exhibits favorable pharmacokinetic and bioavailability profiles for in vivo use. It showed excellent CNS penetration with brain concentrations exceeding that in plasma.
References/Citations:
- Nemec et al. (2024), Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2; J.Med.Chem. 67 12632
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