Muscone | Cardioprotective and neuroprotective agent
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 100 mg | $60.00 | ||
| 500 mg | $240.00 |
Muscone (541-92-3) is a macrocyclic ketone found naturally in a glandular secretion of the musk deer which acts at human odorant receptor OR5AN1 and is used in perfumes.1 It suppresses inflammatory responses and neuronal damage in various models including a rat model of cervical spondylotic myelopathy2 and relieves inflammatory pain acting via the NOX4/JAK2-STAT3 and NLRP3 inflammasome pathway3. In the cardiovascular system it alleviates myocardial ischemia-reperfusion injury4 and improves cardiac function in mice after myocardial infarction5 via enhancement of angiogenesis6.
References/Citations:
- Ahmed et al. (2018), Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds; Proc. Natl. Acad. Sci. USA 115 E3950
- Zhou et al. (2020), Muscone suppresses inflammatory responses and neuronal damage in a rat model of cervical spondylotic myelopathy by regulating Drp1-dependent mitochondrial fission; J. Neurochem. 155 154
- Yu et al. (2020), Muscone relieves inflammatory pain by inhibiting microglial activation-mediated inflammatory response via abrogation of the NOX4/JAK2-STAT3 pathway and NLRP3 inflammasome; Immunopharmacol. 82 106355
- Wei et al. (2021), Muscone alleviates myocardial ischemia-reperfusion injury via inhibition of oxidative stress and enhancement of SIRT3; J. Neurochem. 155 154
- Yu et al. (2020), Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-kB and NLRP3 inflammasome; J. Biol. Regul. Homeost. Agents 35 85
- Du et al. (2018), Hypoxia-Inducible Factor 1 alpha (HIF-1α)/Vascular Endothelial Growth Factor (VEGF) Pathway Participates in Angiogenesis of Myocardial Infarction in Muscone-Treated Mice; Am. J. Transl. Res. 10 4235
C16H30O
>98% by TLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Muscone (541-92-3) is a macrocyclic ketone found naturally in a glandular secretion of the musk deer which acts at human odorant receptor OR5AN1 and is used in perfumes.1 It suppresses inflammatory responses and neuronal damage in various models including a rat model of cervical spondylotic myelopathy2 and relieves inflammatory pain acting via the NOX4/JAK2-STAT3 and NLRP3 inflammasome pathway3. In the cardiovascular system it alleviates myocardial ischemia-reperfusion injury4 and improves cardiac function in mice after myocardial infarction5 via enhancement of angiogenesis6.
References/Citations:
- Ahmed et al. (2018), Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds; Proc. Natl. Acad. Sci. USA 115 E3950
- Zhou et al. (2020), Muscone suppresses inflammatory responses and neuronal damage in a rat model of cervical spondylotic myelopathy by regulating Drp1-dependent mitochondrial fission; J. Neurochem. 155 154
- Yu et al. (2020), Muscone relieves inflammatory pain by inhibiting microglial activation-mediated inflammatory response via abrogation of the NOX4/JAK2-STAT3 pathway and NLRP3 inflammasome; Immunopharmacol. 82 106355
- Wei et al. (2021), Muscone alleviates myocardial ischemia-reperfusion injury via inhibition of oxidative stress and enhancement of SIRT3; J. Neurochem. 155 154
- Yu et al. (2020), Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-kB and NLRP3 inflammasome; J. Biol. Regul. Homeost. Agents 35 85
- Du et al. (2018), Hypoxia-Inducible Factor 1 alpha (HIF-1α)/Vascular Endothelial Growth Factor (VEGF) Pathway Participates in Angiogenesis of Myocardial Infarction in Muscone-Treated Mice; Am. J. Transl. Res. 10 4235
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