Mycophenolic acid | Immunosuppressant
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 100 mg | $50.00 | ||
| 500 mg | $120.00 |
Mycophenolic acid (24280-93-1) is an immunomodulator1 that blocks the biosynthesis of guanine nucleotides via inhibition of inosine 5′-monophosphate dehydrogenase. This in turn suppresses the production of proinflammatory cytokines, nitric oxide and LDH in macrophages2,3. Inhibits IL-2 -dependent T cell proliferation4.
References/Citations
1) Eugui et al. (1991), Lymphocyte-selective cyostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depletion; Scand. J. Immunol., 33 161
2) Jonsson et al. (2002), Mycophenolic acid inhibits inosine 5′-monophosphate dehydrogenase and suppresses production of pro-inflammatory cytokines, nitric oxide and LDH in macrophages; Cell. Immunol., 216 93
3) Allison et al. (1993), Mechanisms of action of mycophenolic acid; Ann. NY Acad. Sci., 696 63
4) Quemeneur et al. (2002), Mycophenolic acid inhibits IL-2-dependent T cell proliferation, but not IL-2-dependent survival and sensitization to apoptosis; J. Immunol., 169 2747
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Mycophenolic acid (24280-93-1) is an immunomodulator1 that blocks the biosynthesis of guanine nucleotides via inhibition of inosine 5′-monophosphate dehydrogenase. This in turn suppresses the production of proinflammatory cytokines, nitric oxide and LDH in macrophages2,3. Inhibits IL-2 -dependent T cell proliferation4.
References/Citations
1) Eugui et al. (1991), Lymphocyte-selective cyostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depletion; Scand. J. Immunol., 33 161
2) Jonsson et al. (2002), Mycophenolic acid inhibits inosine 5′-monophosphate dehydrogenase and suppresses production of pro-inflammatory cytokines, nitric oxide and LDH in macrophages; Cell. Immunol., 216 93
3) Allison et al. (1993), Mechanisms of action of mycophenolic acid; Ann. NY Acad. Sci., 696 63
4) Quemeneur et al. (2002), Mycophenolic acid inhibits IL-2-dependent T cell proliferation, but not IL-2-dependent survival and sensitization to apoptosis; J. Immunol., 169 2747
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1-855-FOCUS21
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