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Myriocin | Blocks sphingolipid biosynthesis

Myriocin (35891-70-4) is a fungal metabolite with potent immunosuppressant activity.1 It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide.2 Myriocin was found to suppress melanoma cell proliferation by cell cycle arrest at the G 2/M phase through decreased sphingolipid levels and increased p53 and p21 (waf1/cip1) expression.3

References/Citations
1) Fujita et al.(1994) Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite; J. Antibiot. 47 208
2) Miyake et al. (1995) Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant ISP-1/myriocin; Biochem. Biophys. Res. Commun. 211 396
3) Lee et al. (2012) Myriocin, a serine palmitoyltransferase inhibitor, suppresses tumor growth in a murine melanoma model by inhibiting de novo sphingolipid synthesis; Cancer Biol Ther. 13 92

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Catalog#  10-2088

$65.00
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CAS:
35891-70-4
Catalog Number:
10-2088
Activity:
Blocks sphingolipid biosynthesis
Alternate Names:
ISP-1
Chemical Name:
(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid
Molecular Weight:
401.54
Molecular Formula:
C21H39NO6
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Off-white solid
Purity:
>98%
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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