Size : | Price | Quantity | |
---|---|---|---|
5 mg | $50.00 | ||
25 mg | $195.00 |
N-Acetyl-S-farnesyl-L-cysteine (AFC) (135304-07-3) inhibits S-farnesylcysteine methyl transferase (Km = 20 µM).1 AFC blocked capacitative Ca2+ influx in human embryonic kidney 293 cells2 and store-regulated Ca2+ entry in human platelets3. Topical AFC has been shown to inhibit neutrophil chemotaxis and other inflammatory responses without systemic effects.4,5
References/Citations:
1) Volker et al. (1991), Effects of farnesylcysteine analogs on protein carboxyl methylation and signal transduction; J. Biol. Chem. 266 21515
2) Xu et al. (1996), Inhibition of capacitative Ca2+ entry into cells by farnesyl analogs; Mol. Pharmacol. 50 1495
3) Rosado and Sage (2000), Farnesylcysteine analogues inhibit store-regulated Ca2+ entry in human platelets: evidence for involvement of small GTP-binding proteins and actin cytoskeleton; Biochem. J. 347 183
4) Gordon et al. (2008), Topical N-acetyl-S-farnesyl-L-cysteine inhibits mouse skin inflammation, and unlike dexamethasone, its effects are restricted to the application site; J. Invest. Dermatol. 128 643
5) Adhami et al. (2012), N-acetyl-S-farnesyl-L-cysteine suppresses chemokine production by human dermal microvascular endothelial cells; Exp. Dermatol. 21 700
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N-Acetyl-S-farnesyl-L-cysteine (AFC) (135304-07-3) inhibits S-farnesylcysteine methyl transferase (Km = 20 µM).1 AFC blocked capacitative Ca2+ influx in human embryonic kidney 293 cells2 and store-regulated Ca2+ entry in human platelets3. Topical AFC has been shown to inhibit neutrophil chemotaxis and other inflammatory responses without systemic effects.4,5
References/Citations:
1) Volker et al. (1991), Effects of farnesylcysteine analogs on protein carboxyl methylation and signal transduction; J. Biol. Chem. 266 21515
2) Xu et al. (1996), Inhibition of capacitative Ca2+ entry into cells by farnesyl analogs; Mol. Pharmacol. 50 1495
3) Rosado and Sage (2000), Farnesylcysteine analogues inhibit store-regulated Ca2+ entry in human platelets: evidence for involvement of small GTP-binding proteins and actin cytoskeleton; Biochem. J. 347 183
4) Gordon et al. (2008), Topical N-acetyl-S-farnesyl-L-cysteine inhibits mouse skin inflammation, and unlike dexamethasone, its effects are restricted to the application site; J. Invest. Dermatol. 128 643
5) Adhami et al. (2012), N-acetyl-S-farnesyl-L-cysteine suppresses chemokine production by human dermal microvascular endothelial cells; Exp. Dermatol. 21 700
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