N-Oleoylphenylalanine | Endogenous Uncoupler of Mitochondrial Respiration

CAS:
136560-78-6
Catalog Number:
10-1602
Activity:
Endogenous Uncoupler of Mitochondrial Respiration
Chemical Name:
N-Oleoyl Phe
Alternate Names:
NOPA, C18-1-Phe
Molecular Weight:
429.64
Molecular Formula:
C27H43NO3
Solubility:
Soluble in DMSO (up to 35 mg/ml)
Physical Properties:
Off-white solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:

Blue Ice

Available Options

Size :PriceQuantity 
5 mg$50.00
25 mg$200.00

N-Oleoylphenylalanine (136560-78-6) is an endogenous lipoamino acid produced via the action of a secreted enzyme PM20D1 produced by adipocytes. N-Oleoylphenylalanine binds directly to mitochondria and functions as an endogenous uncoupler of UCP1-independent respiration and is the most potent in the group of structurally different lipoamino acids evaluated. Mice treated with an analog, C18-1-Leu, were found to have improved glucose homeostasis and increased energy expenditure.1

References/Citations:

1) Long et al. (2016), The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria; Cell, 166 424

CAS:
136560-78-6
Catalog Number:
10-1602
Activity:
Endogenous Uncoupler of Mitochondrial Respiration
Chemical Name:
N-Oleoyl Phe
Alternate Names:
NOPA, C18-1-Phe
Molecular Weight:
429.64
Molecular Formula:
C27H43NO3
Solubility:
Soluble in DMSO (up to 35 mg/ml)
Physical Properties:
Off-white solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:

Blue Ice

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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