Naloxone HCl | Opioid receptor antagonist
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 100 mg | $95.00 | ||
| 500 mg | $280.00 |
Naloxone (357-08-4) is a pan-opioid receptor antagonist, Ki=3.7, 9.2 and 33 nM for m, k and d opioid receptors respectively.1 In clinical use in opiate abuse and overdose rescue.2 Blocks opiate- promoted wound healing.3 Attenuates the pruritic response to rimonabant in a rat model.4
References/Citations
1) Le Bourdonnec et al., (2008), Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles: Bioorg. Med. Chem. Lett.. 18 2006
2) Boyer et al. (2012), Management of opioid analgesic overdose; New Engl. J. Med. 367 146
3) Wang et al. (2017), Opioids and opioid receptors orchestrate wound repair; Transl. Res. 185 13
4) Wright and Rodgers (2013), Low dose naloxone attenuates the pruritic but not anorectic response to rimonabant in male rats; Psychopharmacology (Berl.) 226 415
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Naloxone (357-08-4) is a pan-opioid receptor antagonist, Ki=3.7, 9.2 and 33 nM for m, k and d opioid receptors respectively.1 In clinical use in opiate abuse and overdose rescue.2 Blocks opiate- promoted wound healing.3 Attenuates the pruritic response to rimonabant in a rat model.4
References/Citations
1) Le Bourdonnec et al., (2008), Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles: Bioorg. Med. Chem. Lett.. 18 2006
2) Boyer et al. (2012), Management of opioid analgesic overdose; New Engl. J. Med. 367 146
3) Wang et al. (2017), Opioids and opioid receptors orchestrate wound repair; Transl. Res. 185 13
4) Wright and Rodgers (2013), Low dose naloxone attenuates the pruritic but not anorectic response to rimonabant in male rats; Psychopharmacology (Berl.) 226 415
Related products
-
Nifedipine | L-type Ca channel blocker
From $40.00CAS:21829-25-4Catalog Number:10-1116Activity:L-type Ca channel blockerChemical Name:2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl esterMolecular Weight:346.34Molecular Formula:C17H18N2O6Solubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:Yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions are not stable and must be used within one working day.Shipping Code:RT -
Na Valproate | HDAC inhibitor
$40.00CAS:1069-66-5Catalog Number:10-1009Activity:HDAC inhibitorChemical Name:2-Propylpentanoic acid NaMolecular Weight:166.2Molecular Formula:C8H15O2·NaSolubility:Soluble in Water (up to 50 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 monthsShipping Code:RT -
Verapamil HCl | L-type Ca channel blocker
From $27.00CAS:152-11-4Catalog Number:10-1111Activity:L-type Ca channel blockerChemical Name:5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochlorideMolecular Weight:491.06Molecular Formula:C27H38N2O4·HClSolubility:Soluble in DMSO (up to 20 mg/ml) or in Water (up to 50 mg/ml).Physical Properties:White solidPurity:>98% by TLCStorage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
