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Naloxone HCl | Opioid receptor antagonist

Naloxone (357-08-4) is a pan-opioid receptor antagonist, Ki=3.7, 9.2 and 33 nM for m, k and d opioid receptors respectively.1 In clinical use in opiate abuse and overdose rescue.2 Blocks opiate- promoted wound healing.3 Attenuates the pruritic response to rimonabant in a rat model.4


1) Le Bourdonnec et al., (2008), Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opiod receptor antagonists with improved opiod receptor selectivity profiles: Bioorg. Med. Chem. Lett.. 18 2006
2) Boyer et al. (2012), Management of opioid analgesic overdose; New Engl. J. Med. 367 146
3) Wang et al. (2017), Opioids and opioid receptors orchestrate wound repair; Transl. Res. 185 13
4) Wright and Rodgers (2013), Low dose naloxone attenuates the pruritic but not anorectic response to rimonabant in male rats; Psychopharmacology (Berl.) 226 415

Focus Biomolecules cell signaling supplier, chemical structure of Naloxone HCl | Opioid receptor antagonist | CAS 357-08-4

Catalog#  10-2442

Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
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Catalog Number:
Opiod receptor antagonist
Chemical Name:
(5α)-4,5-Epoxy-3,14-dihydro-17-(2-propenyl)morphinan-6-one hydrochloride
Molecular Weight:
Molecular Formula:
C19H21NO4 &bul; HCl
Soluble in DMSO (up to 25 mg/ml) or in Water (up to 25 mg/ml).
Physical Properties:
White solid
99% by HPLC
NMR (Conforms)
Storage Temperature:
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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