Naloxone (357-08-4) is a pan-opioid receptor antagonist, Ki=3.7, 9.2 and 33 nM for m, k and d opioid receptors respectively1. In clinical use in opiate abuse and overdose rescue.2 Blocks opiate- promoted wound healing.3 Attenuates the pruritic response to rimonabant in a rat model.4.
1) Le Bourdonnec et al., (2008), Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opiod receptor antagonists with improved opiod receptor selectivity profiles: Bioorg. Med. Chem. Lett.. 18 2006
2) Boyer et al. (2012), Management of opioid analgesic overdose; New Engl. J. Med. 367 146
3) Wang et al. (2017), Opioids and opioid receptors orchestrate wound repair; Transl. Res. 185 13
4) Wright and Rodgers (2013), Low dose naloxone attenuates the pruritic but not anorectic response to rimonabant in male rats; Psychopharmacology (Berl.) 226 415