Napabucasin | STAT3 inhibitor / Cancer cell stemness inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $58.00 | ||
| 25 mg | $250.00 |
Napabucasin (83280-65-3) inhibits gene transcription driven by STAT3. Inhibits cancer cell stemness gene expression and blocks spherogenesis of stemness-high cancer cells isolated from a variety of cancer types.1 Effective antitumor agent as a monotherapy or in combination with other agents such as taxol in mouse models.2 Clinical trials have demonstrated encouraging anti-tumor activity with the potential to suppress metastasis and prevent relapse in patients with various types of cancer.2,3 Overcomes cisplatin resistance in non-small cell lung cancer.4
References/Citations:
1) Li et al. (2015), Suppression of cancer relapse and metastasis by inhibiting cancer stemness; Proc. Natl. Acad. Sci. USA, 112 1839
2) Hubbard and Grothey (2017), Napabucasin: an Update on the First-in-Class Cancer Stemness Inhibitor; Drugs, 77 1091
3) Zhang et al. (2016), Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin; Cancer Med., 5 1251
4) MacDonagh et al. (2018), BBI608 inhibits cancer stemness and reverses cisplatin resistance in NSCLC; Cancer Lett., 428 117
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Napabucasin (83280-65-3) inhibits gene transcription driven by STAT3. Inhibits cancer cell stemness gene expression and blocks spherogenesis of stemness-high cancer cells isolated from a variety of cancer types.1 Effective antitumor agent as a monotherapy or in combination with other agents such as taxol in mouse models.2 Clinical trials have demonstrated encouraging anti-tumor activity with the potential to suppress metastasis and prevent relapse in patients with various types of cancer.2,3 Overcomes cisplatin resistance in non-small cell lung cancer.4
References/Citations:
1) Li et al. (2015), Suppression of cancer relapse and metastasis by inhibiting cancer stemness; Proc. Natl. Acad. Sci. USA, 112 1839
2) Hubbard and Grothey (2017), Napabucasin: an Update on the First-in-Class Cancer Stemness Inhibitor; Drugs, 77 1091
3) Zhang et al. (2016), Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin; Cancer Med., 5 1251
4) MacDonagh et al. (2018), BBI608 inhibits cancer stemness and reverses cisplatin resistance in NSCLC; Cancer Lett., 428 117
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