NDI-091143 | Potent allosteric ATP-citrate lyase inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $220.00 |
NDI-091143 (2375840-87-0) is a potent (IC50 = 2.1 nM ADP-Glo assay; 4.8 nM Oxaloacetate coupled enzyme assay) allosteric inhibitor of ATP-citrate lyase.1 NDI-091143 suppressed growth and clonogenic ability in thyroid cancer cell lines FTC-133 and 8505C.2 It also synergistically potentiated the cytotoxicity of sorafenib.2
References/Citations:
- Wei et al. (2019), An allosteric mechanism for potent inhibition of human ATP-citrate lyase; Nature, 568 566
- Huang et al. (2022), ACLY inhibitors induce apoptosis and potentiate cytotoxic effects of sorafenib in thyroid cancer cells; Endocrine, 78 85
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
NDI-091143 (2375840-87-0) is a potent (IC50 = 2.1 nM ADP-Glo assay; 4.8 nM Oxaloacetate coupled enzyme assay) allosteric inhibitor of ATP-citrate lyase.1 NDI-091143 suppressed growth and clonogenic ability in thyroid cancer cell lines FTC-133 and 8505C.2 It also synergistically potentiated the cytotoxicity of sorafenib.2
References/Citations:
- Wei et al. (2019), An allosteric mechanism for potent inhibition of human ATP-citrate lyase; Nature, 568 566
- Huang et al. (2022), ACLY inhibitors induce apoptosis and potentiate cytotoxic effects of sorafenib in thyroid cancer cells; Endocrine, 78 85
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1-855-FOCUS21
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