NDI-091143 | Potent allosteric ATP-citrate lyase inhibitor

CAS:
2375840-87-0
Catalog Number:
10-4841
Activity:
Potent allosteric ACLY inhibitor
Chemical Names:
Methyl 3-Chloro-5-[(2,4-difluoro-5-phenylphenyl)sulfamoyl]-4-hydroxybenzoate
Molecular Weight:
453.84
Molecular Formula:
C20H14ClF2NO5S
Solubility:
Soluble in DMSO (>50 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$60.00
25 mg$220.00
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NDI-091143 (2375840-87-0) is a potent (IC50 = 2.1 nM ADP-Glo assay; 4.8 nM Oxaloacetate coupled enzyme assay) allosteric inhibitor of ATP-citrate lyase.1 NDI-091143 suppressed growth and clonogenic ability in thyroid cancer cell lines FTC-133 and 8505C.2 It also synergistically potentiated the cytotoxicity of sorafenib.2

References/Citations:

  1. Wei et al. (2019), An allosteric mechanism for potent inhibition of human ATP-citrate lyase; Nature, 568 566
  2. Huang et al. (2022), ACLY inhibitors induce apoptosis and potentiate cytotoxic effects of sorafenib in thyroid cancer cells; Endocrine, 78 85

 

CAS:
2375840-87-0
Catalog Number:
10-4841
Activity:
Potent allosteric ACLY inhibitor
Chemical Names:
Methyl 3-Chloro-5-[(2,4-difluoro-5-phenylphenyl)sulfamoyl]-4-hydroxybenzoate
Molecular Weight:
453.84
Molecular Formula:
C20H14ClF2NO5S
Solubility:
Soluble in DMSO (>50 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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