NE-100 | Selective sigma-1 antagonist
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $70.00 | ||
| 25 mg | $225.00 |
NE-100 (149409-57-4) is potent inhibitor of the sigma receptor (σ) with selectivity for sigma-1 (IC50 = 1.5 nM) over sigma-2 (IC50 = 85 nM).1,2 NE-100 suppressed ischemia-induced neuronal cell death in mice via upregulation of GRP78 through the ATF6 pathway resulting in suppression of ER stress-induced cell death in a sigma-1-independent manner.3
References/Citations:
1) Okuyama et al. (1994), NE-100, a novel sigma receptor ligand: in vivo tests; Life Sci. 53 PL285
2) Chaki et al. (1994), NE-100, a novel potent sigma ligand, preferentially binds to sigma 1 binding sites in guinea pig brain; Eur. J. Pharmacol. 251 R1
3) Ono et al. (2013), A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells; Biochem. Biophys. Res. Commun. 434 904
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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NE-100 (149409-57-4) is potent inhibitor of the sigma receptor (σ) with selectivity for sigma-1 (IC50 = 1.5 nM) over sigma-2 (IC50 = 85 nM).1,2 NE-100 suppressed ischemia-induced neuronal cell death in mice via upregulation of GRP78 through the ATF6 pathway resulting in suppression of ER stress-induced cell death in a sigma-1-independent manner.3
References/Citations:
1) Okuyama et al. (1994), NE-100, a novel sigma receptor ligand: in vivo tests; Life Sci. 53 PL285
2) Chaki et al. (1994), NE-100, a novel potent sigma ligand, preferentially binds to sigma 1 binding sites in guinea pig brain; Eur. J. Pharmacol. 251 R1
3) Ono et al. (2013), A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells; Biochem. Biophys. Res. Commun. 434 904
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